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Immunology
Engineered peptides open new avenue for immunotherapy drug development
In a new study published in Nature Biomedical Engineering, researchers at The University of Texas MD Anderson Cancer Center have designed a new method for developing immunotherapy drugs using engineered peptides to elicit ...
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Diseases, Conditions, Syndromes
Signs of multiple sclerosis show up in blood years before symptoms, study finds
In a discovery that could hasten treatment for patients with multiple sclerosis (MS), UC San Francisco scientists have discovered a harbinger in the blood of some people who later went on to develop the disease.
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Medical research news
Study of cancer-induced liver inflammation finds a promising therapeutic target
Liver inflammation, a common side-effect of cancers elsewhere in the body, has long been associated with worse cancer outcomes and more recently associated with poor response to immunotherapy. Now, a team led by researchers ...
2 hours ago
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Immune cells carry a long-lasting 'memory' of early-life pain
In recent years, a growing body of research has shown that the human body can "remember" the pain of newborn injuries—including life-saving surgeries—all the way into adolescence.
15 hours ago
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Study finds that human neuron signals flow in one direction
Contrary to previous assumptions, nerve cells in the human neocortex are wired differently than in mice. Those are the findings of a new study conducted by Charité-Universitätsmedizin Berlin and published in the journal ...
16 hours ago
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A common pathway in the brain that enables addictive drugs to hijack natural reward processing identified
Mount Sinai researchers, in collaboration with scientists at The Rockefeller University, have uncovered a mechanism in the brain that allows cocaine and morphine to take over natural reward processing systems. Published online ...
17 hours ago
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Scientists identify airway cells that sense aspirated water and acid reflux
When a mouthful of water goes down the wrong pipe—heading toward a healthy person's lungs instead of their gut—they start coughing uncontrollably. That's because their upper airway senses the water and quickly signals ...
17 hours ago
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Environment may influence metacognitive abilities more than genetics
Twin studies have proven invaluable for teasing out the effects of both genetics and the environment on human biology. In a study published April 2 in Cell Reports, researchers studied pairs of twins to look at how the interplay ...
17 hours ago
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DNA vaccine against Zika performs well in tests on mice
In Brazil, researchers at the University of São Paulo (USP) and the Pernambuco division of Oswaldo Cruz Foundation (FIOCRUZ) are developing a Zika vaccine. The formulation was tested on mice and found to be efficacious, ...
18 hours ago
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Mutations in noncoding DNA become functional in some cancer-driving genes
Some genes are known to drive cancer, and astonishing new research shows why: Mutations in the noncoding regions become functional, altering the abundance of messenger RNA, or mRNA, and potentially facilitating cell proliferation. ...
18 hours ago
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Large genomic study finds tri-ancestral origins for Japanese population
A multi-institutional team of geneticists and genomic and genotyping specialists in Japan has sequenced the genomes of thousands of Japanese people from across the country, looking to settle the debate surrounding the ancestry ...
Novel cell therapy treatments offer promise to immune-compromised children
In a first-of-its-kind clinical trial, researchers found that intravenous therapies made from virus-specific T-cells (VST) can effectively treat immunocompromised pediatric patients, far surpassing the current standard of ...
18 hours ago
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New urine-based test detects high-grade prostate cancer, helping men avoid unnecessary biopsies
Researchers at the University of Michigan Rogel Cancer Center have developed a new urine-based test that addresses a major problem in prostate cancer: how to separate the slow-growing form of the disease unlikely to cause ...
20 hours ago
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Perfect balance: How the brain fine-tunes its sensitivity
A sensitive perception of the environment is crucial for guiding our behavior. However, an overly sensitive response of the brain's neural circuits to stimuli can lead to neurodevelopmental disorders such as epilepsy. University ...
20 hours ago
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Study shows metabolic health before vaccination determines effectiveness of anti-flu response
Metabolic health (normal blood pressure, blood sugar and cholesterol levels, among other factors) influences the effectiveness of influenza vaccinations. Vaccination is known to be less effective in people with obesity compared ...
20 hours ago
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Researchers reduce bias in pathology AI algorithms and enhance accuracy using foundation models
Advanced artificial intelligence (AI) systems have shown promise in revolutionizing the field of pathology by transforming the detection, diagnosis, and treatment of disease; however, the underrepresentation of certain patient ...
20 hours ago
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Responsiveness to ADHD treatment may be determined by neuroanatomy
New research from the Institute of Psychiatry, Psychology & Neuroscience (IoPPN) at King's College London has found that the effectiveness of ADHD medication may be associated with an individual's neuroanatomy.
20 hours ago
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New heart disease calculator could save lives by identifying high-risk patients missed by current tools
Collaborative research, led from the University of Oxford and published today in Nature Medicine, has developed a new tool called QR4 that more accurately predicts an individual's 10-year risk of cardiovascular diseases, ...
20 hours ago
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Long COVID patients show immunological improvement two years after infection
Biomarkers for long COVID that were present in patients at eight months have largely resolved by 24 months among a cohort of people who contracted COVID-19 during Australia's first wave.
21 hours ago
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Siblings with unique genetic mutation help scientists progress drug search for type 1 diabetes
Two siblings who have the only known mutations in a key gene anywhere in the world have helped scientists gain new insights that could help progress the search for new treatments in type 1 diabetes.
21 hours ago
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