Archive: 11/13/2011
New approaches may prevent certain side effects in BRAF mutation-positive melanoma
Findings from preclinical studies in a skin cancer model showed that next-generation BRAF inhibitors used alone, or first-generation BRAF inhibitors used in combination with an epidermal growth factor receptor inhibitor, ...
Cancer
Nov 13, 2011 |
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BUSM: Severe sepsis, new-onset AF associated with increased risk of hospital stroke, death
A recent study led by researchers at Boston University School of Medicine (BUSM) shows an increased risk of stroke and mortality among patients diagnosed with severe sepsis and new-onset atrial fibrillation (AF) during hospitalization.
Diseases, Conditions, Syndromes
Nov 13, 2011 |
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Improved memory efficiency seen after aerobic exercise in fibromyalgia patients
Areas of the brain responsible for pain processing and cognitive performance changed in fibromyalgia patients who exercised following a medication holiday, say researchers from Georgetown University Medical Center. They say ...
Neuroscience
Nov 13, 2011 |
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Researchers develop more effective way to discover and test potential cancer drugs
Researchers have created a new phenotypic screening platform that better predicts success of drugs developed to prevent blood vessel tumor growth when moving out of the lab and onto actual tumors.
Cancer
Nov 13, 2011 |
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Novel monoclonal antibody offers potential treatment for tumors resistant to VEGF therapy
Despite the widespread use of current antiangiogenic cancer therapies, many tumors escape this blockade, which is designed to shut down growth of new blood vessels that feed tumors and spread cancer cells. Now, a study reported ...
Cancer
Nov 13, 2011 |
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Combination therapy shows potent tumor growth inhibition in preclinical studies
Combining the investigational agents REGN910 and aflibercept yielded statistically significant improvements in antitumor effects in animal models compared with either agent alone, according to results presented at the AACR-NCI-EORTC ...
Cancer
Nov 13, 2011 |
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'Moonlighting' enzyme unravels arginine paradox
(Medical Xpress) -- Nearly 20 years ago, the journal Science tagged nitric oxide as the "molecule of the year." Since that time, researchers have tried to study and target this simple molecule that is involved in virtually every ...
Medical research
Nov 13, 2011 |
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Newly identified gene mutation adds to melanoma risk
A major international study has identified a novel gene mutation that appears to increase the risk of both inherited and sporadic cases of malignant melanoma, the most deadly form of skin cancer. The identified mutation occurs ...
Cancer
Nov 13, 2011 |
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Bacterial genes tell the tale of an outbreak's evolution
Researchers at Harvard Medical School and Children's Hospital Boston have retraced the evolution of an unusual bacterial infection as it spread among cystic fibrosis patients by sequencing scores of samples collected during ...
Genetics
Nov 13, 2011 |
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Ultrathin flexible brain implant offers unique look at seizures
Researchers funded by the National Institutes of Health have developed a flexible brain implant that could one day be used to treat epileptic seizures. In animal studies, the researchers used the device – ...
Neuroscience
Nov 13, 2011 |
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Researchers find surprising role for enzyme in tumor cell division and new drug to combat it
Researchers at the University of California, San Diego School of Medicine and the UC San Diego Moores Cancer Center have identified a new drug discovery approach enabling the destruction of the most highly ...
Cancer
Nov 13, 2011 |
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Study: New drug cuts deaths after heart attack
People recovering from a heart attack or severe chest pain are much less likely to suffer another heart-related problem or to die from one if they take a new blood-thinning drug along with standard anti-clotting medicines, ...
Cardiology
Nov 13, 2011 |
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Benefit of novel drug in breast cancer seen in blood within weeks
Clinical benefit from use of a novel histone deacetylase inhibitor drug may be determined by examining blood cells days after a patient receives treatment. The drug, entinostat, is the first histone deacetylase inhibitor ...
Cancer
Nov 13, 2011 |
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Signaling pathway linked to inflammatory breast cancer may drive disease metastasis
Amplification of anaplastic lymphoma kinase, which has been reported in other cancers such as non-small cell lung cancers, may be a primary driver of the rapid metastasis that patients with inflammatory breast cancer experience.
Inflammatory disorders
Nov 13, 2011 |
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Low vitamin C levels may raise heart failure patients' risk
Low levels of vitamin C were associated with higher levels of high sensitivity C-Reactive protein (hsCRP) and shorter intervals without major cardiac issues or death for heart failure patients, in research presented at the ...
Cardiology
Nov 13, 2011 |
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