Diseases, Conditions, Syndromes

Some 'anaphylactic' reactions to flu shots may just be stress responses

Some adverse reactions to influenza vaccinations may be safe to de-labeled—that is, deemed safe for further flu vaccinations—from "allergies" to "stress-related responses" because they do not meet the criteria for anaphylaxis, ...

Diseases, Conditions, Syndromes

Anaphylactic shock after vaccination 'extremely rare'

A sudden, serious allergic reaction -- known anaphylaxis or anaphylactic shock -- following vaccination, is "extremely rare," concludes research published online in the Archives of Disease in Childhood.

Medical research

Longer needles recommended for epinephrine autoinjectors

(HealthDay)—Given the increasing epidemic of obesity, epinephrine autoinjectors (EAIs) for anaphylaxis require longer needles to ensure intramuscular injection, according to a study published online Feb. 13 in Allergy.

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Anaphylaxis is defined as "a serious allergic reaction that is rapid in onset and may cause death". It typically results in a number of symptoms including an itchy rash, throat swelling, and low blood pressure. Common causes include insect bites, foods, and medications.

On a pathophysiologic level, anaphylaxis is due to the release of mediators from certain types of white blood cells triggered either by immunologic or non-immunologic mechanisms. It is diagnosed based on the presenting symptoms and signs. The primary treatment is injection of epinephrine, with other measures being complementary.

Worldwide 0.05–2% of people are estimated to have anaphylaxis at some point in their life and rates appear to be increasing. The term comes from the Greek words ἀνά ana, against, and φύλαξις phylaxis, protection.

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