(HealthDay)—In the war against cancer, it looks like matchmaking—between genes and drugs—could be an important tool, according to new research into the genetic underpinnings of two rare forms of leukemia.
Cancer May 09, 2013 | not rated yet | 0
A single antibody could be the key to treating multiple myeloma, or cancer of the blood, currently without cure or long-term treatment.
Cancer May 06, 2013 | 5 / 5 (1) | 0
A team of researchers led by Washington University School of Medicine in St. Louis has identified virtually all of the major mutations that drive acute myeloid leukemia (AML), a fast-growing blood cancer ...
Cancer May 01, 2013 | 5 / 5 (1) | 0 |
Powerful data-sifting algorithms developed by computer scientists at Brown University are helping to untangle the profoundly complex genetics of cancer. In a study reported today in the New England Journal of Medicine, resear ...
Cancer May 01, 2013 | not rated yet | 0 |
More than 100 doctors from around the world have signed a letter decrying the high cost of cancer drugs which reach $100,000 per year or more, and calling for pharmaceutical companies to ease prices.
Medications Apr 26, 2013 | 5 / 5 (4) | 2
Researchers from the RIKEN Center for Integrative Medical Sciences in Japan report today that they have identified a compound that could be used as a new treatment to prevent relapse in acute myeloid leukemia patients.
Cancer Apr 17, 2013 | 5 / 5 (2) | 0 |
A new study on how the progression of acute lymphocytic leukemia (ALL) is influenced by the bone marrow environment has demonstrated for the first time that targeting a specialized protein known as osteopontin (OPN) may be ...
Cancer Apr 15, 2013 | not rated yet | 0
Academia-industry partnership creates blueprint for collaboration to develop innovative new cancer treatment
Canadians and patients around the world with the misfortune to be diagnosed with one of the deadliest forms of leukemia may soon be able to thank a multi-faceted collaboration in Montreal's biopharmaceutical cluster for giving ...
Cancer Apr 12, 2013 | not rated yet | 0
In a surprising finding that helps explain fundamental behaviors of normal and diseased cells, Whitehead Institute scientists have discovered a set of powerful gene regulators dubbed "super-enhancers" that control cell state ...
Cancer Apr 11, 2013 | 4.8 / 5 (6) | 0 |
Just like a massive iceberg jutting out of the ocean, many of cancer's genetic underpinnings remain hidden under the surface, impossible to predict or map from above. The foreboding shadows and shapes that appear on CT scans ...
Cancer Apr 05, 2013 | not rated yet | 0
Recently, research using adoptive T-cell immunotherapy in blood cancers have shown success, most notably in the case of a seven-year-old girl whose leukemia went into remission using altered T-cells and a disabled HIV virus. ...
Cancer Apr 03, 2013 | 5 / 5 (1) | 0
Researchers from the Centre for Genomic Regulation (CRG) in Barcelona reprogramme lymphoma and leukaemia cells to halt their malignancy. Resulting cells remain benign even when no longer subjected to treatment and reduce ...
Cancer Apr 03, 2013 | 5 / 5 (4) | 0
Researchers at Mayo Clinic Cancer Center have developed new guidelines to treat recently diagnosed multiple myeloma patients who are not participating in clinical trials. The guidelines give physicians practical, easy to ...
Cancer Apr 01, 2013 | not rated yet | 0
Scientists at the University of York have discovered the driving force behind the development of prostate cancer.
Cancer Mar 27, 2013 | 5 / 5 (2) | 0
Researchers at the University of California, San Diego Moores Cancer Center have identified a humanized monoclonal antibody that targets and directly kills chronic lymphocytic leukemia (CLL) cells.
Cancer Mar 25, 2013 | 5 / 5 (4) | 0 |
Hematological malignancies are the types of cancer that affect blood, bone marrow, and lymph nodes. As the three are intimately connected through the immune system, a disease affecting one of the three will often affect the others as well: although lymphoma is technically a disease of the lymph nodes, it often spreads to the bone marrow, affecting the blood and occasionally producing a paraprotein.
While uncommon in solid tumors, chromosomal translocations are a common cause of these diseases. This commonly leads to a different approach in diagnosis and treatment of hematological malignancies.
Hematological malignancies are malignant neoplasms ("cancer"), and they are generally treated by specialists in hematology and/or oncology. In some centers "Hematology/oncology" is a single subspecialty of internal medicine while in others they are considered separate divisions (there are also surgical and radiation oncologists). Not all hematological disorders are malignant ("cancerous"); these other blood conditions may also be managed by a hematologist.
Hematological malignancies may derive from either of the two major blood cell lineages: myeloid and lymphoid cell lines. The myeloid cell line normally produces granulocytes, erythrocytes, thrombocytes, macrophages and mast cells; the lymphoid cell line produces B, T, NK and plasma cells. Lymphomas, lymphocytic leukemias, and myeloma are from the lymphoid line, while acute and chronic myelogenous leukemia, myelodysplastic syndromes and myeloproliferative diseases are myeloid in origin.
This text uses material from Wikipedia and is available under the GNU Free Documentation License.
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