Human tumors transplanted into laboratory mice disappeared or shrank when scientists treated the animals with a single antibody, according to a new study from the Stanford University School of Medicine. The antibody works ...
Cancer Mar 26, 2012 | 5 / 5 (12) | 0 |
(Medical Xpress) -- Researchers in Britain revealed Friday they are exploring whether the nightclubbers' drug ecstasy could be effective in treating blood cancers.
Medications Aug 19, 2011 | 5 / 5 (11) | 2 |
(Medical Xpress)—University of Washington scientists have succeeded in removing the extra copy of chromosome 21 in cell cultures derived from a person with Down syndrome, a condition in which the body's ...
Medical research Nov 09, 2012 | 4.9 / 5 (11) | 0 |
In a surprising finding that helps explain fundamental behaviors of normal and diseased cells, Whitehead Institute scientists have discovered a set of powerful gene regulators dubbed "super-enhancers" that control cell state ...
Cancer Apr 11, 2013 | 4.8 / 5 (6) | 0 |
The development of a male contraceptive pill has long proven to be elusive, but findings from a new study may point scientists in the right direction to making oral birth control for men a reality.
Medical research Aug 16, 2012 | 4.3 / 5 (6) | 2 |
Hundreds of mutations exist in leukemia cells at the time of diagnosis, but nearly all occur randomly as a part of normal aging and are not related to cancer, new research shows.
Genetics Jul 19, 2012 | 5 / 5 (5) | 3 |
As blood stem cells age, changes in the epigenome—the system that regulates which genes are switched on and which are switched off throughout the body—alter these cells in ways that lead to reduced immune ...
Medical research Feb 15, 2013 | 5 / 5 (5) | 0 |
(Medical Xpress)—Scientists at the Medical Research Council (MRC) Laboratory of Molecular Biology have found that stem cells in the body's 'blood cell factory'—the bone marrow—are extremely sensitive to the main breakdown ...
Medical research Aug 27, 2012 | 4.8 / 5 (5) | 0 |
A new genetic defect that predisposes people to acute myeloid leukemia and myelodysplasia has been discovered. The mutations were found in the GATA2 gene. Among its several regulatory roles, the gene acts ...
Genetics Sep 04, 2011 | 5 / 5 (4) | 0 |
(Medical Xpress) -- Cancer Research UK scientists have discovered a promising new approach to treat a type of myeloid leukaemia a cancer with limited treatment options and relatively poor survival, according to research ...
Cancer Mar 30, 2012 | 5 / 5 (4) | 0
Researchers at the University of California, San Diego Moores Cancer Center have identified a humanized monoclonal antibody that targets and directly kills chronic lymphocytic leukemia (CLL) cells.
Cancer Mar 25, 2013 | 5 / 5 (4) | 0 |
Researchers from the Centre for Genomic Regulation (CRG) in Barcelona reprogramme lymphoma and leukaemia cells to halt their malignancy. Resulting cells remain benign even when no longer subjected to treatment and reduce ...
Cancer Apr 03, 2013 | 5 / 5 (4) | 0
More than 100 doctors from around the world have signed a letter decrying the high cost of cancer drugs which reach $100,000 per year or more, and calling for pharmaceutical companies to ease prices.
Medications Apr 26, 2013 | 5 / 5 (4) | 2
(Medical Xpress) -- Scientists have uncovered a critical genetic mutation in some patients with myelodysplastic syndromes a group of blood cancers that can progress to a fatal form of leukemia.
Genetics Dec 14, 2011 | 4.8 / 5 (4) | 0 |
Growing up on a livestock farm seems to be linked to an increased risk of developing blood cancers as an adult, indicates research published online in Occupational and Environmental Medicine.
Cancer Jul 28, 2011 | 5 / 5 (3) | 0
Hematological malignancies are the types of cancer that affect blood, bone marrow, and lymph nodes. As the three are intimately connected through the immune system, a disease affecting one of the three will often affect the others as well: although lymphoma is technically a disease of the lymph nodes, it often spreads to the bone marrow, affecting the blood and occasionally producing a paraprotein.
While uncommon in solid tumors, chromosomal translocations are a common cause of these diseases. This commonly leads to a different approach in diagnosis and treatment of hematological malignancies.
Hematological malignancies are malignant neoplasms ("cancer"), and they are generally treated by specialists in hematology and/or oncology. In some centers "Hematology/oncology" is a single subspecialty of internal medicine while in others they are considered separate divisions (there are also surgical and radiation oncologists). Not all hematological disorders are malignant ("cancerous"); these other blood conditions may also be managed by a hematologist.
Hematological malignancies may derive from either of the two major blood cell lineages: myeloid and lymphoid cell lines. The myeloid cell line normally produces granulocytes, erythrocytes, thrombocytes, macrophages and mast cells; the lymphoid cell line produces B, T, NK and plasma cells. Lymphomas, lymphocytic leukemias, and myeloma are from the lymphoid line, while acute and chronic myelogenous leukemia, myelodysplastic syndromes and myeloproliferative diseases are myeloid in origin.
This text uses material from Wikipedia and is available under the GNU Free Documentation License.
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