Large-scale genetic study defines relationship between primary sclerosing cholangitis and other autoimmune diseases
For the first time, scientists show that a leading cause of liver transplant, primary sclerosing cholangitis (PSC), is a distinct disease from inflammatory bowel disease, opening up new avenues for specific PSC treatments.
Genetics Apr 21, 2013 | not rated yet | 0 |
With every meal, immune cells in the intestine stand like sentries at a citadel, turning away harmful bacteria but allowing vitamins and nutrients to pass.
Immunology Mar 14, 2012 | 5 / 5 (4) | 0 |
An international team of scientists led by the University of Leicester has found new evidence that links faster 'biological' ageing to the risk of developing several age-related diseases - including heart disease, multiple ...
Genetics Mar 27, 2013 | 4 / 5 (1) | 0 |
(HealthDay)—Modifying an infant's diet to include the protein gluten while the mother is still breast-feeding could lower the risk of celiac disease, a common intestinal disorder, according to a new Swedish ...
Pediatrics Feb 19, 2013 | 5 / 5 (2) | 0 |
Dana-Farber Cancer Institute scientists have demonstrated a new strategy for treating autoimmune disease that successfully blocked the development of rheumatoid arthritis in a mouse model. They say it holds promise for improved ...
Arthritis & Rheumatism Feb 08, 2013 | 5 / 5 (3) | 0 |
A type of immune cell found in the small intestine plays a previously unsuspected role in monitoring antigens circulating in the bloodstream. The findings from a team of Massachusetts General Hospital (MGH) researchers clarify ...
Immunology Dec 13, 2012 | 5 / 5 (1) | 0 |
(Medical Xpress)—There is no benefit for the average healthy adult to follow a gluten-free diet, according to research published by an Arizona State University professor in the September 2012 issue of the Journal of th ...
Health Oct 10, 2012 | not rated yet | 0 |
(Medical Xpress)—Researchers have long known that individual diseases are associated with genes in specific locations of the genome. Genetics researchers at the University of North Carolina at Chapel Hill now have shown ...
Genetics Sep 19, 2012 | not rated yet | 0 |
(HealthDay) -- Early vaccinations do not seem to influence the risk of celiac disease (CD) among infants, nor do changes in the vaccination program explain the CD epidemic, according to a Swedish study published ...
Diseases, Conditions, Syndromes Jun 25, 2012 | not rated yet | 0 |
Australian researchers have uncovered a potential new way to regulate the bodys natural immune response, offering hope of a simple and effective treatment for auto-immune diseases.
Immunology May 31, 2012 | 5 / 5 (1) | 0 |
Human geneticists have long debated whether the genetic risk of the most common medical conditions derive from many rare mutations, each conferring a high degree of risk in different people, or common differences throughout ...
Genetics Mar 25, 2012 | 5 / 5 (1) | 0 |
Researchers at the University of Colorado School of Medicine have found a specific molecule that can prevent the development of type 1 diabetes in mice and has a similar effect on human cells from diabetic patients.
Medical research Nov 01, 2011 | 5 / 5 (5) | 0 |
The team of researchers from the Universities of Bristol, Queensland. Oxford, Texas and Toronto, used a technique called genome-wide association where millions of genetic markers are measured in thousands of people that have ...
Genetics Jul 10, 2011 | 5 / 5 (2) | 0 |
(HealthDay)—For people with celiac disease, an accurate diagnosis and proper diet are essential for good health, experts say.
Diseases, Conditions, Syndromes May 10, 2013 | not rated yet | 0
Pregnant women with mid to high levels of antibodies common in patients with celiac disease are at risk for having babies with reduced fetal weight and birth weight, according to a new study in Gastroenterology, the offici ...
Diseases, Conditions, Syndromes Apr 29, 2013 | not rated yet | 0
Coeliac disease ( /ˈsiːli.æk/; spelled celiac disease in North America and often celiac sprue) is an autoimmune disorder of the small intestine that occurs in genetically predisposed people of all ages from middle infancy onward. Symptoms include chronic diarrhoea, failure to thrive (in children), and fatigue, but these may be absent, and symptoms in other organ systems have been described.
A growing portion of diagnoses are being made in asymptomatic persons as a result of increased screening; the condition is thought to affect between 1 in 1,750 and 1 in 105 people in the United States. Coeliac disease is caused by a reaction to gliadin, a prolamin (gluten protein) found in wheat, and similar proteins found in the crops of the tribe Triticeae (which includes other common grains such as barley and rye). Upon exposure to gliadin, and specifically to three peptides found in prolamins, the enzyme tissue transglutaminase modifies the protein, and the immune system cross-reacts with the small-bowel tissue, causing an inflammatory reaction. That leads to a truncating of the villi lining the small intestine (called villous atrophy). This interferes with the absorption of nutrients, because the intestinal villi are responsible for absorption. The only known effective treatment is a lifelong gluten-free diet. While the disease is caused by a reaction to wheat proteins, it is not the same as wheat allergy.
This condition has several other names, including: cœliac disease (with œ ligature), c(o)eliac sprue, non-tropical sprue, endemic sprue, gluten enteropathy or gluten-sensitive enteropathy, and gluten intolerance. The term coeliac derives from the Greek κοιλιακός (koiliakós, "abdominal"), and was introduced in the 19th century in a translation of what is generally regarded as an ancient Greek description of the disease by Aretaeus of Cappadocia.
This text uses material from Wikipedia and is available under the GNU Free Documentation License.
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