Celiac Disease

The pros and cons of going gluten-free

The number of Americans adopting gluten-free diets has grown dramatically over the past several years. Some avoid eating wheat, barley, and rye because they have an autoimmune disorder called celiac disease, ...

Jul 16, 2014
popularity 3 / 5 (6) | comments 0

The molecular heart of celiac disease revealed

Australian, US and Dutch researchers have determined the molecular details of the interaction between the immune system and gluten that triggers celiac disease. Their work opens the way to potential treatments ...

Apr 29, 2014
popularity 4.8 / 5 (5) | comments 1

Bowel illnesses sometimes coincide in kids

(HealthDay)—Children suffering from irritable bowel syndrome are four times more likely than other kids to have a condition called celiac disease—an allergy to gluten—Italian researchers report.

Apr 21, 2014
popularity 3 / 5 (1) | comments 0

Coeliac disease ( /ˈsiːli.æk/; spelled celiac disease in North America and often celiac sprue) is an autoimmune disorder of the small intestine that occurs in genetically predisposed people of all ages from middle infancy onward. Symptoms include chronic diarrhoea, failure to thrive (in children), and fatigue, but these may be absent, and symptoms in other organ systems have been described.

A growing portion of diagnoses are being made in asymptomatic persons as a result of increased screening; the condition is thought to affect between 1 in 1,750 and 1 in 105 people in the United States. Coeliac disease is caused by a reaction to gliadin, a prolamin (gluten protein) found in wheat, and similar proteins found in the crops of the tribe Triticeae (which includes other common grains such as barley and rye). Upon exposure to gliadin, and specifically to three peptides found in prolamins, the enzyme tissue transglutaminase modifies the protein, and the immune system cross-reacts with the small-bowel tissue, causing an inflammatory reaction. That leads to a truncating of the villi lining the small intestine (called villous atrophy). This interferes with the absorption of nutrients, because the intestinal villi are responsible for absorption. The only known effective treatment is a lifelong gluten-free diet. While the disease is caused by a reaction to wheat proteins, it is not the same as wheat allergy.

This condition has several other names, including: cœliac disease (with œ ligature), c(o)eliac sprue, non-tropical sprue, endemic sprue, gluten enteropathy or gluten-sensitive enteropathy, and gluten intolerance. The term coeliac derives from the Greek κοιλιακός (koiliakós, "abdominal"), and was introduced in the 19th century in a translation of what is generally regarded as an ancient Greek description of the disease by Aretaeus of Cappadocia.

This text uses material from Wikipedia licensed under CC BY-SA

Latest Spotlight News

Even depressed people believe that life gets better

Adults typically believe that life gets better—today is better than yesterday was and tomorrow will be even better than today. A new study shows that even depressed individuals believe in a brighter future, but this optimistic ...

Team untangles the biological effects of blue light

Blue light can both set the mood and set in motion important biological responses. Researchers at the University of Pennsylvania's School of Medicine and School of Arts and Sciences have teased apart the ...

Supercomputers link proteins to drug side effects

New medications created by pharmaceutical companies have helped millions of Americans alleviate pain and suffering from their medical conditions. However, the drug creation process often misses many side ...

Magnesium cuts diabetes risk

Getting enough magnesium in the diet may reduce the risk of diabetes, especially for those who already show signs of heading that way.