Diseases, Conditions, Syndromes

Potential cholera vaccine target discovered

Findings from a team led by investigators at Massachusetts General Hospital (MGH), reported in the online journal mBio, may help scientists develop a more effective vaccine for cholera, a bacterial disease that causes severe ...

Diseases, Conditions, Syndromes

Cause of 1990s Argentina cholera epidemic uncovered

The evolution of epidemic and endemic strains of the cholera-causing bacterium Vibrio cholerae in Argentina has been mapped in detail by researchers at the Wellcome Sanger Institute, the London School of Hygiene and Tropical ...

Diseases, Conditions, Syndromes

Leiden cholera epidemics mapped out, literally

Three cholera epidemics struck 19th-century Leiden. Today's coronavirus pandemic prompted Martijn Storms, curator of maps and atlases at the Leiden University Libraries, to scour the library for maps about these past epidemics.

Diseases, Conditions, Syndromes

Mystery of Yemen cholera epidemic solved

The most likely source of the cholera epidemic in Yemen has been discovered by scientists. Through the use of genomic sequencing, scientists at the Wellcome Sanger Institute and Institut Pasteur estimate the strain of cholera ...

Diseases, Conditions, Syndromes

How cholera bacteria make people so sick

The enormous adaptability of the cholera bacterium explains why it is able to claim so many victims. Professor Ariane Briegel from the Leiden Institute of Biology has now discovered that this adaptability is due to rapid ...

Genetics

Cholera spread tracked at household level

For the first time, the transmission of cholera has been tracked at the household level across Dhaka, Bangladesh, a city with a 'hyper-endemic' level of the disease. Researchers from the Wellcome Sanger Institute and their ...

Diseases, Conditions, Syndromes

Risk of cholera epidemics estimated with new rule-book

Cholera has repeatedly traveled out of Asia to cause epidemics in Africa and Latin America, an international research team has found. Researchers at the Wellcome Trust Sanger Institute, Institut Pasteur in France, and collaborators ...

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Cholera is an infection of the small intestine caused by the bacterium Vibrio cholerae. The main symptoms are profuse, watery diarrhea and vomiting. Transmission occurs primarily by drinking water or eating food that has been contaminated by the feces of an infected person (even an asymptomatic one). The severity of the diarrhea and vomiting can lead to rapid dehydration and electrolyte imbalance, and death in some cases. The primary treatment is with oral rehydration solution (ORS) to replace water and electrolytes; if this is not tolerated or does not provide quick enough treatment, intravenous fluids can also be used. Antibiotics are beneficial in those with severe disease to shorten its duration and severity. Worldwide, it affects 3–5 million people and causes 100,000–130,000 deaths a year as of 2010[update]. Cholera was one of the earliest infections to be studied by epidemiological methods.

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