A chronic disease is a disease or other human health condition that is persistent or long-lasting in nature. The term chronic is usually applied when the course of the disease lasts for more than three months. Common chronic diseases include asthma, cancer, diabetes and HIV/AIDS.

In medicine, the opposite of chronic is acute. A chronic course is further distinguished from a recurrent course; recurrent diseases relapse repeatedly, with periods of remission in between.

While often referred to as "non-communicable diseases", also usually lasting medical conditions, the latter are distinguished by their non-infectious cause. In contrast, some chronic diseases, such as HIV/AIDS, are caused by transmissible infections.

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