Chronic Myelogenous Leukemia
Cancer drug prevents build-up of toxic brain protein
Researchers at Georgetown University Medical Center have used tiny doses of a leukemia drug to halt accumulation of toxic proteins linked to Parkinson's disease in the brains of mice. This finding provides the basis to plan ...
Genetics
May 10, 2013 |
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Researchers to develop next generation immunotherapy for children with deadly solid tumors
Recently, research using adoptive T-cell immunotherapy in blood cancers have shown success, most notably in the case of a seven-year-old girl whose leukemia went into remission using altered T-cells and a disabled HIV virus. ...
Cancer
Apr 03, 2013 |
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Researchers study use of dasatinib for patients with high-risk MDS
Researchers at Moffitt Cancer Center have completed a phase II clinical trial to determine the safety and efficacy of dasatinib for patients with higher-risk myelodysplastic syndromes (MDS), chronic myelomonocytic leukemia, ...
Cancer
Mar 21, 2013 |
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Synribo approved to treat rare leukemia
(HealthDay)—Synribo (omacetaxine mepesuccinate) has been approved by the U.S. Food and Drug Administration to treat a rare blood and bone marrow disease called chronic myelogenous leukemia (CML).
Cancer
Oct 26, 2012 |
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FDA approves Pfizer drug for rare blood cancer
Pfizer Inc. says the Food and Drug Administration on Tuesday approved its new drug to treat a rare form of blood and bone marrow cancer.
Medications
Sep 04, 2012 |
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Study pinpoints a genetic cause of most lethal brain tumor, may lead to new treatment
Researchers at Columbia University Medical Center (CUMC) have discovered that some cases of glioblastoma, the most common and aggressive form of primary brain cancer, are caused by the fusion of two adjacent ...
Cancer
Jul 26, 2012 |
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Genome analysis of brain tumors showing the way to new treatment strategies
Brain tumors are the primary cause of cancer mortality in children. Even if a cure is possible, young patients often suffer from the stressful treatment which can be harmful to the developing brain. The most common childhood ...
Cancer
Jul 26, 2012 |
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BIM gene variation in East Asians found to explain resistance to cancer drugs
A multi-national research team led by scientists at Duke-NUS Graduate Medical School has identified the reason why some patients fail to respond to some of the most successful cancer drugs.
Cancer
Mar 18, 2012 |
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Cancer drugs could halt Ebola virus
Some cancer drugs used to treat patients with leukemia may also help stop the Ebola virus and give the body time to control the infection before it turns deadly, US researchers said on Wednesday.
Medications
Feb 29, 2012 |
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Therapy targets leukemia stem cells
New research takes aim at stubborn cancer stem cells that are thought to be responsible for treatment resistance and relapse. The study, published by Cell Press in the February 14 issue of the journal Cancer Cell, provid ...
Cancer
Feb 13, 2012 |
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Fish oil may hold key to leukemia cure
A compound produced from fish oil that appears to target leukemia stem cells could lead to a cure for the disease, according to Penn State researchers. The compound -- delta-12-protaglandin J3, or D12-PGJ3 ...
Cancer
Dec 22, 2011 |
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Cancer-related pathway reveals potential treatment target for rare pediatric disease
Cancer researchers studying genetic mutations that cause leukemia have discovered a connection to the rare disease cherubism, an inherited facial bone disorder in children.
Cancer
Dec 08, 2011 |
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Age no longer a barrier to stem cell transplantation for older patients
Age alone no longer should be considered a defining factor when determining whether an older patient with blood cancer is a candidate for stem cell transplantation. That's the conclusion of the first study summarizing long-term ...
Cancer
Nov 01, 2011 |
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Obesity or stem cell research could win Nobel
Two scientists who unlocked some of the mysteries linked to obesity or a professor who figured out how to make stem cells without human embryos could be candidates for the medicine award when the first of ...
Medical research
Oct 02, 2011 |
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Discovery of gene fusion in ovarian cancer could lead to earlier diagnoses
About 15 percent of cases of an aggressive, difficult-to-detect form of ovarian cancer contain a unique fusion between two neighboring, normally separate genes, say researchers at the Stanford University School of Medicine. ...
Genetics
Sep 20, 2011 |
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Chronic myelogenous (or myeloid) leukemia (CML), also known as chronic granulocytic leukemia (CGL), is a cancer of the white blood cells. It is a form of leukemia characterized by the increased and unregulated growth of predominantly myeloid cells in the bone marrow and the accumulation of these cells in the blood. CML is a clonal bone marrow stem cell disorder in which proliferation of mature granulocytes (neutrophils, eosinophils, and basophils) and their precursors is the main finding. It is a type of myeloproliferative disease associated with a characteristic chromosomal translocation called the Philadelphia chromosome. CML is now largely treated with tyrosine kinase inhibitors (TKIs), such as imatinib, dasatinib, or nilotinib, which have led to dramatically improved survival rates since their introduction in the last decade.
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