Creutzfeldt–Jakob disease ( /ˈkrɔɪtsfɛlt ˈjɑːkoʊb/ kroits-felt ya-kob) or CJD is a degenerative neurological disorder (brain disease) that is incurable and invariably fatal. CJD is at times called a human form of mad cow disease, given that bovine spongiform encephalopathy is believed to be the cause of variant Creutzfeldt–Jakob disease in humans.
CJD is the most common among the types of transmissible spongiform encephalopathy found in humans. In CJD, the brain tissue develops holes and takes on a sponge-like texture. This is due to a type of infectious protein called a prion. Prions are misfolded proteins which replicate by converting their properly folded counterparts.
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