MIT scientists have identified a potential new strategy for treating Fragile X syndrome, a disorder that is the leading heritable cause of intellectual disability and autism.
May 20, 2020
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95
Researchers at the National Institutes of Health have discovered in mice what they believe is the first known genetic mutation to improve cognitive flexibility—the ability to adapt to changing situations.
Mar 27, 2020
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395
Over half of our genomes are made of repeating elements within DNA. In rare cases, these repeats can become unstable and grow in size. These repeat "expansions" cause neurodegenerative diseases such as ALS and dementia as ...
Feb 17, 2020
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A new stand-alone test can more precisely diagnose people with a common genetic cause of autism than the current testing regime.
Oct 28, 2019
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It was long believed the FMR1 premutation—an excessive number of trinucleotide repeats in the FMR1 gene—had no direct effect on the people who carry it. Until recently, the only recognized effect on the carriers of the ...
Aug 21, 2019
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Children with an inherited form of intellectual disability and autism could be helped by a medicine commonly used to lower cholesterol, if used early in life.
May 29, 2019
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Researchers at Emory University School of Medicine have gained insight into a feature of fragile X syndrome, which is also seen in other neurological and neurodevelopmental disorders.
Feb 8, 2019
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In a class of roughly 30 neurological disorders that includes ALS, Huntington's Disease and Fragile X Syndrome, the relevant mutant gene features sections of repeating base pair sequences known as short tandem repeats, or ...
Sep 18, 2018
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25
New work from Carnegie's Ethan Greenblatt and Allan Spradling reveals that the genetic factors underlying fragile X syndrome, and potentially other autism-related disorders, stem from defects in the cell's ability to create ...
Aug 16, 2018
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In a new study in mice, researchers have identified a key protein involved in the irregular brain cell activity seen in autism spectrum disorders and epilepsy. The protein, p53, is well-known in cancer biology as a tumor ...
Jul 17, 2018
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