Gene fusions can lead to glioblastoma in children

Every year, about 60 children and adolescents in Germany are diagnosed with glioblastoma, a very aggressive type of brain cancer, which is still mostly untreatable. Now, scientists from the Max Planck Institute for Molecular ...

Oct 20, 2016
popularity30 comments 0

Custom-tailored strategy against glioblastomas

Glioblastomas are incurable malignant brain tumors. Usually the patients affected survive for only a few months. In addition, every tumor is quite different, which makes treatment very difficult. Researchers at the University ...

Sep 26, 2016
popularity2 comments 0

Glioblastoma multiforme (GBM) is the most common and most aggressive malignant primary brain tumor in humans, involving glial cells and accounting for 52% of all functional tissue brain tumor cases and 20% of all intracranial tumors. Despite being the most prevalent form of primary brain tumor, GBMs occur in only 2–3 cases per 100,000 people in Europe and North America. According to the WHO classification of the tumors of the central nervous system‎, the standard name for this brain tumor is "glioblastoma"; it presents two variants: giant cell glioblastoma and gliosarcoma. Glioblastomas are also an important brain tumor in canines, and research continues to use this as a model for developing treatments in humans.

Treatment can involve chemotherapy, radiation, radiosurgery, corticosteroids, antiangiogenic therapy, surgery and experimental approaches such as gene transfer.

With the exception of the brainstem gliomas, glioblastoma has the worst prognosis of any central nervous system (CNS) malignancy, despite multimodality treatment consisting of open craniotomy with surgical resection of as much of the tumor as possible, followed by concurrent or sequential chemoradiotherapy, antiangiogenic therapy with bevacizumab, gamma knife radiosurgery, and symptomatic management with corticosteroids. Prognosis is poor, with a median survival time of approximately 14 months.

This text uses material from Wikipedia licensed under CC BY-SA

Latest Spotlight News

Mitochondria control stem cell fate

What happens in intestinal epithelial cells during a chronic illness? Basic research conducted at the Chair of Nutrition and Immunology at the Technical University of Munich (TUM) addressed this question by generating a new ...

New approach tests the strength of immunity

The immune system orchestrates large and small scale attacks on innumerous targets: viruses, bacteria, cancer, but it also misfires causing allergy or autoimmune reactions. Compounding the problem, not every immune reaction ...

Want to exercise more? Get yourself some competition

Imagine you're a CEO trying to get your employees to exercise. Most health incentive programs have an array of tools—pamphlets, websites, pedometers, coaching, team activities, step challenges, money—but what actually ...