Glioblastoma
Hundreds of alterations and potential drug targets to starve cancer tumors identified
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Cancer
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Immortality gene mutation identifies brain tumors, other cancers
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Cancer
Mar 18, 2013 |
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New immune therapy treats brain tumors in mice
Using an artificial protein that stimulates the body's natural immune system to fight cancer, a research team at Duke Medicine has engineered a lethal weapon that kills brain tumors in mice while sparing ...
Immunology
Dec 17, 2012 |
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Patient's own immune cells may blunt viral therapy for brain cancer
Doctors now use cancer-killing viruses to treat some patients with lethal, fast-growing brain tumors. Clinical trials show that these therapeutic viruses are safe but less effective than expected.
Cancer
Nov 25, 2012 |
3.7 / 5 (3) |
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Detection, analysis of 'cell dust' may allow diagnosis, monitoring of brain cancer
A novel miniature diagnostic platform using nuclear magnetic resonance (NMR) technology is capable of detecting minuscule cell particles known as microvesicles in a drop of blood. Microvesicles shed by cancer ...
Medical research
Nov 11, 2012 |
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New study finds brain tumors can arise from neurons
(Medical Xpress)—Researchers from the US and Japan have shown that an aggressive type of brain tumor can arise from normal cells in the central nervous system such as neurons. The cells revert to an earlier, ...
Cancer
Oct 19, 2012 |
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Aggressive cancer exploits MYC oncogene to amplify global gene activity
Whitehead Institute researchers have determined the mechanism used by c-Myc to increase the expression of all active genes in cancer cells. Elevated levels of c-Myc are linked to increased rates of metastasis, disease recurrence, ...
Cancer
Sep 27, 2012 |
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Reseach reveals genomic similarities between breast cancer, ovarian cancers
One subtype of breast cancer shares many genetic features with high-grade serous ovarian cancer, a cancer that is very difficult to treat, according to researchers supported by the National Institutes of ...
Cancer
Sep 23, 2012 |
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Study suggests new treatment target for glioblastoma multiforme
A study by UT Southwestern Medical Center researchers published online today in Nature reveals new insight into why the most common, deadly kind of brain tumor in adults recurs and identifies a potential target ...
Cancer
Aug 01, 2012 |
5 / 5 (1) |
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Study pinpoints a genetic cause of most lethal brain tumor, may lead to new treatment
Researchers at Columbia University Medical Center (CUMC) have discovered that some cases of glioblastoma, the most common and aggressive form of primary brain cancer, are caused by the fusion of two adjacent ...
Cancer
Jul 26, 2012 |
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Scientists link 'oncometabolite' to onset of acute myeloid leukemia
A team of international scientists led by principal investigator Dr. Tak Mak at the Princess Margaret Cancer Centre, University Health Network, has identified a causative link between the product of a mutated metabolic enzyme ...
Cancer
Jul 04, 2012 |
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Imipramine blue: Novel compound halts tumor spread, improves brain cancer treatment in animal studies
Treating invasive brain tumors with a combination of chemotherapy and radiation has improved clinical outcomes, but few patients survive longer than two years after diagnosis. The effectiveness of the treatment ...
Cancer
Mar 28, 2012 |
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Photoacoustic tomography can 'see' in color and detail several inches beneath the skin
Every new imaging technology has an aura of magic about it because it suddenly reveals what had been concealed, and makes visible what had been invisible. So, too, with photoacoustic tomography, which is allowing ...
Medical research
Mar 22, 2012 |
4.9 / 5 (8) |
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Study finds mutations tied to aggressive childhood brain tumors
Researchers studying a rare, lethal childhood tumor of the brainstem discovered that nearly 80 percent of the tumors have mutations in genes not previously tied to cancer. Early evidence suggests the alterations play a unique ...
Genetics
Jan 29, 2012 |
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Seeing what's inside a tumor
Gliomas, the most common types of brain tumor, are also among the deadliest cancers: Their mortality rate is nearly 100 percent, in part because there are very few treatments available.
Medical research
Jan 12, 2012 |
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Glioblastoma multiforme (GBM) is the most common and most aggressive malignant primary brain tumor in humans, involving glial cells and accounting for 52% of all functional tissue brain tumor cases and 20% of all intracranial tumors. Despite being the most prevalent form of primary brain tumor, GBMs occur in only 2–3 cases per 100,000 people in Europe and North America. According to the WHO classification of the tumors of the central nervous system, the standard name for this brain tumor is "glioblastoma"; it presents two variants: giant cell glioblastoma and gliosarcoma. Glioblastomas are also an important brain tumor in canines, and research continues to use this as a model for developing treatments in humans.
Treatment can involve chemotherapy, radiation, radiosurgery, corticosteroids, antiangiogenic therapy, surgery and experimental approaches such as gene transfer.
With the exception of the brainstem gliomas, glioblastoma has the worst prognosis of any central nervous system (CNS) malignancy, despite multimodality treatment consisting of open craniotomy with surgical resection of as much of the tumor as possible, followed by concurrent or sequential chemoradiotherapy, antiangiogenic therapy with bevacizumab, gamma knife radiosurgery, and symptomatic management with corticosteroids. Prognosis is poor, with a median survival time of approximately 14 months.
This text uses material from Wikipedia and is available under the GNU Free Documentation License.
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