Glioblastoma

Gene therapy against brain cancer

Only a few days ago, the press (especially in English-speaking countries) enthusiastically announced the publication of a study that described in great detail the genetics of breast cancer, a discovery that according to many ...

May 13, 2016
popularity10 comments 0

Mapping the routes to drug resistance in cancer

When a freeway shuts down because of an accident or construction, drivers find another road to take them where they're going. Likewise, when a targeted therapy blocks a pathway that enables tumors to grow, the cells usually ...

Apr 11, 2016
popularity1 comments 0

Glioblastoma multiforme (GBM) is the most common and most aggressive malignant primary brain tumor in humans, involving glial cells and accounting for 52% of all functional tissue brain tumor cases and 20% of all intracranial tumors. Despite being the most prevalent form of primary brain tumor, GBMs occur in only 2–3 cases per 100,000 people in Europe and North America. According to the WHO classification of the tumors of the central nervous system‎, the standard name for this brain tumor is "glioblastoma"; it presents two variants: giant cell glioblastoma and gliosarcoma. Glioblastomas are also an important brain tumor in canines, and research continues to use this as a model for developing treatments in humans.

Treatment can involve chemotherapy, radiation, radiosurgery, corticosteroids, antiangiogenic therapy, surgery and experimental approaches such as gene transfer.

With the exception of the brainstem gliomas, glioblastoma has the worst prognosis of any central nervous system (CNS) malignancy, despite multimodality treatment consisting of open craniotomy with surgical resection of as much of the tumor as possible, followed by concurrent or sequential chemoradiotherapy, antiangiogenic therapy with bevacizumab, gamma knife radiosurgery, and symptomatic management with corticosteroids. Prognosis is poor, with a median survival time of approximately 14 months.

This text uses material from Wikipedia licensed under CC BY-SA

Latest Spotlight News

Rio athletes may benefit from 'leaky gut' therapy

'Leaky gut' is a condition where the thin mucosal barrier of the gut, which plays a role in absorbing nutrients and preventing large molecules and germs from the gut entering the blood stream, becomes less effective.

Viral protein silences immune alarm signals

Viruses must avoid a host's immune system to establish successful infections—and scientists have discovered another tool that viruses use to frustrate host defenses. Researchers from The Children's Hospital of Philadelphia ...