Hemolytic Uremic Syndrome

Certain mutations affect kidney disease risk and prognosis

Certain gene mutations affect individuals' risk of developing a serious kidney condition, as well as their prognosis after being diagnosed with the disease, according to a study appearing in an upcoming issue of the Journal of ...

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French woman dies of E. coli

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The war on microbes

The outbreak of a new foodborne bacterial strain wreaking havoc in Germany is a reminder of the fast-changing nature of microbes and the dangers they pose to society. University of Arizona researchers are ...

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Hemolytic-uremic syndrome (or haemolytic-uraemic syndrome), abbreviated HUS, is a disease characterized by hemolytic anemia (anemia caused by destruction of red blood cells), acute kidney failure (uremia) and a low platelet count (thrombocytopenia). It predominantly, but not exclusively, affects children. Most cases are preceded by an episode of infectious, sometimes bloody, diarrhea caused by E. coli O157:H7, which is acquired as a foodborne illness or from a contaminated water supply. It is a medical emergency and carries a 5–10% mortality; of the remainder, the majority recover without major consequences but a small proportion develop chronic kidney disease and become reliant on renal replacement therapy. HUS was first defined as a syndrome in 1955.

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