Liver Transplant

New gene therapy methods accurately correct mutation in patient's stem cells

For the first time, scientists have cleanly corrected a human gene mutation in a patient's stem cells. The result, reported in Nature on Wednesday 12 October, brings the possibility of patient-specific therapies closer to bec ...

Genetics created Oct 12, 2011 | popularity 4.6 / 5 (10) | comments 0 | with audio podcast

Scientists shed light on how liver repairs itself

Scientists have shed light on how the liver repairs itself with research that could help develop drugs to treat liver disease.

Medical research created Mar 04, 2012 | popularity 5 / 5 (9) | comments 0 | with audio podcast

Adult stem cells take root in livers and repair damage

Johns Hopkins researchers have demonstrated that human liver cells derived from adult cells coaxed into an embryonic state can engraft and begin regenerating liver tissue in mice with chronic liver damage.

Medical research created May 11, 2011 | popularity 4.3 / 5 (6) | comments 2 | with audio podcast

Researchers discover how hepatitis C virus reprograms human liver cells

Hepatitis C virus has evolved to invade and hijack the basic machinery of the human liver cell to ensure its survival and spread. Researchers at the University of North have discovered how hepatitis C binds ...

Diseases, Conditions, Syndromes created Dec 18, 2012 | popularity 5 / 5 (5) | comments 0 | with audio podcast

First trial of a new hepatitis C vaccine shows promise

(Medical Xpress) -- A new vaccine against the chronic liver disease hepatitis C has shown promising results in a first clinical trial in humans, Oxford University researchers report.

Diseases, Conditions, Syndromes created Jan 05, 2012 | popularity 5 / 5 (4) | comments 0 | with audio podcast

'Stimulated' stem cells stop donor organ rejection

(Medical Xpress) -- Johns Hopkins researchers have developed a way to stimulate a rat’s stem cells after a liver transplant as a means of preventing rejection of the new organ without the need for lifelong immunosuppressant ...

Medical research created Oct 18, 2011 | popularity 3.8 / 5 (5) | comments 2 | with audio podcast

Computer modeling reveals how surprisingly potent hepatitis C drug works

A study by researchers from Los Alamos National Laboratory and a multinational team reveals how daclatasvir, a direct-acting antiviral agent in development for the treatment of hepatitis C virus (HCV), targets one of its ...

Diseases, Conditions, Syndromes created Feb 18, 2013 | popularity 4.8 / 5 (4) | comments 0 | with audio podcast

Duplicating immunity boosting regulatory T-cells to unprecedented levels

University of Minnesota Medical School researchers have discovered a method to quickly and exponentially grow regulatory T-cells – also known as "suppressor cells." The new process enables replication of the cells by ...

Medical research created May 18, 2011 | popularity 5 / 5 (3) | comments 0 | with audio podcast

Pancreatic cancer 4th most deadly, treatments few

(AP) -- Pancreatic cancer is notoriously lethal - there are almost as many deaths from it each year as there are new cases. The deaths this week of Apple founder Steve Jobs and Nobelist Ralph Steinman bring ...

Cancer created Oct 08, 2011 | popularity 3.8 / 5 (4) | comments 0

Paracetamol: Repeated ingestion of slightly too much can be fatal -- recognize and treat quickly

Repeatedly taking slightly too much paracetamol over time can cause a dangerous overdose that is difficult to spot, but puts the person at danger of dying. Patients may not come to hospital reporting the overdose, but because ...

Medications created Nov 23, 2011 | popularity 5 / 5 (3) | comments 6

Scientists find promising vaccine targets on hepatitis C virus

A team led by scientists at The Scripps Research Institute has found antibodies that can prevent infection from widely differing strains of hepatitis C virus (HCV) in cell culture and animal models.

Diseases, Conditions, Syndromes created Apr 03, 2012 | popularity 5 / 5 (3) | comments 0 | with audio podcast

Study reveals how the world's first drug for amyloid disease works

Scientists from The Scripps Research Institute and Pfizer Inc. have published a new study showing how a new drug called tafamidis (Vyndaqel) works. Tafamidis, approved for use in Europe and currently under ...

Medical research created May 29, 2012 | popularity 5 / 5 (3) | comments 0 | with audio podcast

CDC to baby boomers: Get tested for hepatitis C

(AP) -- For the first time, health officials are proposing that all baby boomers get tested for hepatitis C.

Diseases, Conditions, Syndromes created May 18, 2012 | popularity 4.7 / 5 (3) | comments 0

Unsolved puzzle in hepatology on the brink of resolution

Primary sclerosing cholangitis is a currently incurable liver disease that mostly affects younger people aged between 30 and 40. There are now justified hopes that this disease could be cured using synthetically ...

Diseases, Conditions, Syndromes created Feb 25, 2013 | popularity 5 / 5 (2) | comments 1

Entry point for hepatitis C infection identified

A molecule embedded in the membrane of human liver cells that aids in cholesterol absorption also allows the entry of hepatitis C virus, the first step in hepatitis C infection, according to research at the University of ...

Diseases, Conditions, Syndromes created Jan 24, 2012 | popularity 4.5 / 5 (2) | comments 0 | with audio podcast


Liver transplantation or hepatic transplantation is the replacement of a diseased liver with a healthy liver allograft. The most commonly used technique is orthotopic transplantation, in which the native liver is removed and replaced by the donor organ in the same anatomic location as the original liver. Liver transplantation nowadays is a well accepted treatment option for end-stage liver disease and acute liver failure. Typically three surgeons and one anesthesiologist are involved, with up to four supporting nurses. The surgical procedure is very demanding and ranges from 4 to 18 hours depending on outcome. Numerous anastomoses and sutures, and many disconnections and reconnections of abdominal and hepatic tissue, must be made for the transplant to succeed, requiring an eligible recipient and a well-calibrated live or cadaveric donor match. By any standard, hepatic transplantation is a major surgical procedure with an appreciable degree of risk.[citation needed]

This text uses material from Wikipedia and is available under the GNU Free Documentation License.

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