Lung Cancer

Uncovering a new pathway to halting metastasis

Metastasis, the process by which cancer cells leave the primary tumor and spread to other sites in the body, is responsible for more than 90 percent of cancer deaths. Thus, there is a significant need to improve the therapeutic ...

Aug 19, 2016
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Team compares effectiveness of four PD-L1 tests

In a recent study, a Yale Cancer Center team compared the performance of the four available PD-L1 assay tests. They found that one of the assays failed to reveal comparable levels of PD-L1, a tumor-promoting protein, while ...

Sep 23, 2016
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Targeted therapies beneficial in KRAS-mutated NSCLC

(HealthDay)—Targeted therapies that do not contain erlotinib can be beneficial for patients with KRAS-mutated (KRAS mut+) advanced non-small-cell lung cancer (NSCLC), according to a study published online Aug. 1 in the ...

Aug 03, 2016
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Oxygen can impair cancer immunotherapy in mice

Researchers have identified a mechanism in mice by which anticancer immune responses are inhibited within the lungs, a common site of metastasis for many cancers. This mechanism involves oxygen inhibition of the anticancer ...

Aug 25, 2016
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Taking aim at rare cancer variants

If you walked into a cancer clinic ten years ago as a newly diagnosed patient, you'd likely get "standard of care" treatment based on the location of the cancer in your body and its stage. Make that same visit today and your ...

Jul 29, 2016
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Healing virus 'Rigvir' can double cancer survival rates

Strangely enough, cancer patients across the world seem to have come to terms with the fact that the most effective treatment against cancer - chemotherapy - actually destroys their immune system. In Latvia, however, a breakthrough ...

Aug 31, 2016
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Lung cancer is a disease characterized by uncontrolled cell growth in tissues of the lung. If left untreated, this growth can spread beyond the lung in a process called metastasis into nearby tissue and, eventually, into other parts of the body. Most cancers that start in lung, known as primary lung cancers, are carcinomas that derive from epithelial cells. Worldwide, lung cancer is the most common cause of cancer-related death in men and women, and is responsible for 1.3 million deaths annually, as of 2004. The most common symptoms are shortness of breath, coughing (including coughing up blood), and weight loss.

The main types of lung cancer are small-cell lung cancer (SCLC), also called oat cell cancer, and non-small-cell lung cancer (NSCLC). The most common cause of lung cancer is long-term exposure to tobacco smoke. Nonsmokers account for 15% of lung cancer cases, and these cases are often attributed to a combination of genetic factors, radon gas, asbestos, and air pollution including secondhand smoke.

Lung cancer may be seen on chest radiograph and computed tomography (CT scan). The diagnosis is confirmed with a biopsy. This is usually performed by bronchoscopy or CT-guided biopsy. Treatment and prognosis depend on the histological type of cancer, the stage (degree of spread), and the patient's general wellbeing, measured by performance status. Common treatments include surgery, chemotherapy, and radiotherapy. NSCLC is sometimes treated with surgery, whereas SCLC usually responds better to chemotherapy and radiation therapy. This is partly because SCLC often spreads quite early, and these treatments are generally better at getting to cancer cells that have spread to other parts of the body.

Survival depends on stage, overall health, and other factors, but overall 14% of people in the United States diagnosed with lung cancer survive five years after the diagnosis.

This text uses material from Wikipedia licensed under CC BY-SA

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