Maintaining a stocked cart, with a full supply of the life-saving drug dantrolene, to treat malignant hyperthermia, a rare but potentially fatal adverse reaction to general anesthesia, may not be cost-beneficial in hospital ...
Apr 18, 2018
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New research published online in The FASEB Journal may ultimately help athletes and trainers better understand who may be more at risk for heat stroke. In the report, scientists use animals to show that there is a link between ...
May 11, 2017
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(HealthDay)—If you have surgery on your calendar, don't wait until the last minute to start preparing, especially if you're going to need anesthesia.
Apr 7, 2017
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The New Balance Falmouth Road Race is one of the premier running events of the summer season, drawing an estimated 75,000 spectators, who strain to catch a glimpse of Olympic-caliber runners as they tear through a scenic ...
Aug 14, 2015
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We've all seen the story in the news before. Whether it's the death of a physically fit high school athlete at football training camp in August, or of an elderly woman gardening in the middle of the day in July, heat stroke ...
Jan 8, 2012
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Malignant hyperthermia (MH) or malignant hyperpyrexia is a rare life-threatening condition that is usually triggered by exposure to certain drugs used for general anesthesia; specifically, the volatile anesthetic agents and the neuromuscular blocking agent, succinylcholine. In susceptible individuals, these drugs can induce a drastic and uncontrolled increase in skeletal muscle oxidative metabolism, which overwhelms the body's capacity to supply oxygen, remove carbon dioxide, and regulate body temperature, eventually leading to circulatory collapse and death if not treated quickly.
Susceptibility to MH is often inherited as an autosomal dominant disorder, for which there are at least 6 genetic loci of interest, most prominently the ryanodine receptor gene (RYR1). MH susceptibility is phenotypically and genetically related to central core disease (CCD), an autosomal dominant disorder characterized both by MH symptoms and myopathy. MH is usually revealed by anesthesia, or when a family member develops the symptoms. There is no simple, straightforward test to diagnose the condition. When MH develops during a procedure, treatment with dantrolene sodium is usually initiated; dantrolene and the avoidance of anesthesia in susceptible people have markedly reduced the mortality from this condition.
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