Melanoma

Factors ID'd for MAPK treatment outcome in melanoma

(HealthDay)—For patients with metastatic melanoma treated with mitogen-activated protein kinase (MAPK) inhibitors, gender, serum lactate dehydrogenase (LDH), BRAF genotype, and primary melanoma ulceration status are independent ...

Aug 03, 2015
popularity14 comments 0

Discovery may lead to targeted melanoma therapies

Melanoma patients with high levels of a protein that controls the expression of pro-growth genes are less likely to survive, according to a study led by researchers at Icahn School of Medicine at Mount Sinai and published ...

Jun 17, 2015
popularity28 comments 0

Trials show immune drugs effective in advanced melanomas

Results of two clinical trials reported at the American Society for Clinical Oncology (ASCO) Annual Meeting 2015 show continued promise of immune therapies nivolumab and pembrolizumab against advanced melanomas, specifically ...

Jun 01, 2015
popularity8 comments 0

AACR: ICMgp100 tolerated, active in advanced melanoma

(HealthDay)—An affinity-enhanced T cell receptor specific for the human leukocyte antigen-A2 restricted melanoma gp 100 peptide fused to an anti-CD3 antibody fragment, IMCgp100, seems promising for advanced melanoma, according ...

Apr 09, 2014
popularity0 comments 0

A tiny RNA with a big role in melanoma

A Yale-led study has identified a key mechanism in the regulation of gene expression that promotes the proliferation of melanoma cells. The finding opens a possible avenue for development of treatments that target this mechanism. ...

Feb 18, 2014
popularity0 comments 0

Modified immune cells seek and destroy melanoma

In this issue of the Journal of Clinical Investigation, researchers led by Scott Pruitt at Duke University and Merck Research Laboratories report on a human clinical trial in which modified dendritic cells, a component of ...

Jun 24, 2013
popularity0 comments 0

Melanoma i/ˌmɛləˈnoʊmə/ (from Greek μέλας - melas, "dark") is a malignant tumor of melanocytes. Melanocytes are cells that produce the dark pigment, melanin, which is responsible for the color of skin. They predominantly occur in skin, but are also found in other parts of the body, including the bowel and the eye (see uveal melanoma). Melanoma can occur in any part of the body that contains melanocytes.

Melanoma is less common than other skin cancers. However, it is much more dangerous and causes the majority (75%) of deaths related to skin cancer. Worldwide, doctors diagnose about 160,000 new cases of melanoma yearly. The diagnosis is more frequent in women than in men and is particularly common among Caucasians living in sunny climates, with high rates of incidence in Australia, New Zealand, North America, Latin America, and northern Europe. According to a WHO report, about 48,000 melanoma related deaths occur worldwide per year.

The treatment includes surgical removal of the tumor, adjuvant treatment, chemo- and immunotherapy, or radiation therapy. The chance of a cure is greatest when the tumor is discovered while it is still small and thin, and can be entirely removed surgically.

This text uses material from Wikipedia licensed under CC BY-SA

Latest Spotlight News

Study finds possible new jet-lag treatment

Exposing people to short flashes of light while they're sleeping could provide a fast and efficient method of preventing jet lag, according to a study by researchers at the Stanford University School of Medicine.

Gut environment could reduce severity of malaria

Microorganisms in the gut could play a role in reducing the severity of malaria, according to a new study co-authored by researchers at the University of Tennessee, Knoxville, and the University of Louisville.

Timebomb in the testicles investigated

Oxford scientists have for the first time been able to identify the origins of some severe disease-causing mutations within the testicles of healthy men. This discovery will help our understanding of how certain serious genetic ...

Study examines evolution of cancer

A novel Yale study answers age-old questions about how cancers spread by applying tools from evolutionary biology. The new insights will help scientists better understand the genetic origins of tumor metastases, and lead ...

Sleep deprivation linked to false confessions

Sleep-deprived people are much more likely to sign false confessions than rested individuals, according to a groundbreaking study that has important implications for police interrogation practices.