Melanoma

Melanoma: Whole-genome sequencing of 25 tumors confirms role of sun damage, reveals new genetic alterations

Melanoma – the deadliest and most aggressive form of skin cancer – has long been linked to time spent in the sun. Now a team led by scientists from the Broad Institute and Dana-Farber Cancer Institute has sequenced ...

Cancer created May 09, 2012 | popularity 5 / 5 (5) | comments 2 | with audio podcast

Women have clear melanoma survival advantage over men

(HealthDay) -- Women with localized melanoma have a consistent advantage over men of approximately 30 percent for survival and progression, according to a study published online April 30 in the Journal of ...

Cancer created May 01, 2012 | popularity 5 / 5 (1) | comments 0

Second mutation in BRAF-mutated melanoma doesn't contribute to resistance

A second mutation found in the tumors of patients with BRAF-mutated metastatic melanoma does not contribute to resistance to BRAF inhibitor drugs, a finding that runs counter to what scientists expected to be true.

Cancer created Apr 01, 2012 | popularity 5 / 5 (1) | comments 0 | with audio podcast

Study reveals trigger that may speed melanoma growth

(HealthDay) -- Growth of the deadly skin cancer melanoma may be triggered by the immune system turning on itself, according to a new study that also identified the mechanism that causes this to happen.

Cancer created Mar 28, 2012 | popularity 5 / 5 (3) | comments 0 | with audio podcast

Ipilimumab active in advanced melanoma with brain mets

(HealthDay) -- For some patients with advanced melanoma and brain metastases, ipilimumab is active, according to the results of a phase 2 study published online March 27 in The Lancet Oncology.

Cancer created Mar 27, 2012 | popularity not rated yet | comments 0

Researchers building melanoma vaccine to combat skin cancer

Mayo Clinic researchers have trained mouse immune systems to eradicate skin cancer from within, using a genetic combination of human DNA from melanoma cells and a cousin of the rabies virus. The strategy, called cancer immunotherapy, ...

Cancer created Mar 19, 2012 | popularity 5 / 5 (11) | comments 0 | with audio podcast

Response rate high for some patients with metastatic melanoma treated with vemurafenib

An international team of researchers from the United States and Australia, including researchers at Moffitt Cancer Center in Tampa, Fla., have found that the oral BRAF inhibitor vemurafenib (PLX4032) when tested in a phase ...

Cancer created Mar 16, 2012 | popularity 5 / 5 (1) | comments 0 | with audio podcast

Activities, smoking affect lymph node involvement in melanoma

(HealthDay) -- Several factors, including sporting activity, physical workload, and smoking habits, affect the sonomorphologic characteristics of peripheral lymph nodes (LNs) in patients with a history of ...

Cancer created Mar 09, 2012 | popularity not rated yet | comments 0

Systemic tumor disappearance following local radiation treatment reported in metastatic melanoma patient

A rarely seen phenomenon in cancer patients — in which focused radiation to the site of one tumor is associated with the disappearance of metastatic tumors all over the body — has been reported in a patient with ...

Cancer created Mar 07, 2012 | popularity 4 / 5 (1) | comments 0

Scientists uncover mechanism for melanoma drug resistance

Cancer is tough to kill and has many ways of evading the drugs used by oncologists to try and eliminate it.

Cancer created Mar 06, 2012 | popularity 5 / 5 (4) | comments 0 | with audio podcast

Using patients' own tumor-fighting cells to knock back advanced melanoma

A small, early-phase clinical trial to test the effectiveness of treating patients with advanced melanoma using billions of clones of their own tumor-fighting cells combined with a specific type of chemotherapy has shown ...

Cancer created Mar 05, 2012 | popularity 4.8 / 5 (5) | comments 0 | with audio podcast

Retinol supplementation may lower melanoma risk

(HealthDay) -- Retinol supplementation is associated with a lower risk of melanoma, according to research published online March 1 in the Journal of Investigative Dermatology.

Cancer created Mar 05, 2012 | popularity not rated yet | comments 1

New drug, Vemurafenib, doubles survival of metastatic melanoma patients

A report published this week in the New England Journal of Medicine shows that the 50 percent of metastatic melanoma patients with a specific genetic mutation benefit from the drug Vemurafenib – increasing median surviv ...

Cancer created Mar 01, 2012 | popularity 5 / 5 (4) | comments 0

Researchers find potential solution to melanoma's resistance to vemurafenib

Researchers at Moffitt Cancer Center in Tampa, Fla., and colleagues in California have found that the XL888 inhibitor can prevent resistance to the chemotherapy drug vemurafenib, commonly used for treating patients with melanoma.

Cancer created Feb 28, 2012 | popularity not rated yet | comments 0 | with audio podcast

New melanoma drug Zelboraf nearly doubles survival in majority of patients

Investigators from Vanderbilt-Ingram Cancer Center (VICC) and 12 other centers in the United States and Australia have found that a new drug for patients with metastatic melanoma nearly doubled median overall survival.

Cancer created Feb 22, 2012 | popularity 5 / 5 (2) | comments 0 | with audio podcast


Melanoma i/ˌmɛləˈnoʊmə/ (from Greek μέλας - melas, "dark") is a malignant tumor of melanocytes. Melanocytes are cells that produce the dark pigment, melanin, which is responsible for the color of skin. They predominantly occur in skin, but are also found in other parts of the body, including the bowel and the eye (see uveal melanoma). Melanoma can occur in any part of the body that contains melanocytes.

Melanoma is less common than other skin cancers. However, it is much more dangerous and causes the majority (75%) of deaths related to skin cancer. Worldwide, doctors diagnose about 160,000 new cases of melanoma yearly. The diagnosis is more frequent in women than in men and is particularly common among Caucasians living in sunny climates, with high rates of incidence in Australia, New Zealand, North America, Latin America, and northern Europe. According to a WHO report, about 48,000 melanoma related deaths occur worldwide per year.

The treatment includes surgical removal of the tumor, adjuvant treatment, chemo- and immunotherapy, or radiation therapy. The chance of a cure is greatest when the tumor is discovered while it is still small and thin, and can be entirely removed surgically.

This text uses material from Wikipedia and is available under the GNU Free Documentation License.

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