Melanoma: Whole-genome sequencing of 25 tumors confirms role of sun damage, reveals new genetic alterations
Melanoma the deadliest and most aggressive form of skin cancer has long been linked to time spent in the sun. Now a team led by scientists from the Broad Institute and Dana-Farber Cancer Institute has sequenced ...
Cancer May 09, 2012 | 5 / 5 (5) | 2 |
(HealthDay) -- Women with localized melanoma have a consistent advantage over men of approximately 30 percent for survival and progression, according to a study published online April 30 in the Journal of ...
Cancer May 01, 2012 | 5 / 5 (1) | 0
A second mutation found in the tumors of patients with BRAF-mutated metastatic melanoma does not contribute to resistance to BRAF inhibitor drugs, a finding that runs counter to what scientists expected to be true.
Cancer Apr 01, 2012 | 5 / 5 (1) | 0 |
(HealthDay) -- Growth of the deadly skin cancer melanoma may be triggered by the immune system turning on itself, according to a new study that also identified the mechanism that causes this to happen.
Cancer Mar 28, 2012 | 5 / 5 (3) | 0 |
(HealthDay) -- For some patients with advanced melanoma and brain metastases, ipilimumab is active, according to the results of a phase 2 study published online March 27 in The Lancet Oncology.
Cancer Mar 27, 2012 | not rated yet | 0
Mayo Clinic researchers have trained mouse immune systems to eradicate skin cancer from within, using a genetic combination of human DNA from melanoma cells and a cousin of the rabies virus. The strategy, called cancer immunotherapy, ...
Cancer Mar 19, 2012 | 5 / 5 (11) | 0 |
An international team of researchers from the United States and Australia, including researchers at Moffitt Cancer Center in Tampa, Fla., have found that the oral BRAF inhibitor vemurafenib (PLX4032) when tested in a phase ...
Cancer Mar 16, 2012 | 5 / 5 (1) | 0 |
(HealthDay) -- Several factors, including sporting activity, physical workload, and smoking habits, affect the sonomorphologic characteristics of peripheral lymph nodes (LNs) in patients with a history of ...
Cancer Mar 09, 2012 | not rated yet | 0
Systemic tumor disappearance following local radiation treatment reported in metastatic melanoma patient
A rarely seen phenomenon in cancer patients in which focused radiation to the site of one tumor is associated with the disappearance of metastatic tumors all over the body has been reported in a patient with ...
Cancer Mar 07, 2012 | 4 / 5 (1) | 0
Cancer is tough to kill and has many ways of evading the drugs used by oncologists to try and eliminate it.
Cancer Mar 06, 2012 | 5 / 5 (4) | 0 |
A small, early-phase clinical trial to test the effectiveness of treating patients with advanced melanoma using billions of clones of their own tumor-fighting cells combined with a specific type of chemotherapy has shown ...
Cancer Mar 05, 2012 | 4.8 / 5 (5) | 0 |
(HealthDay) -- Retinol supplementation is associated with a lower risk of melanoma, according to research published online March 1 in the Journal of Investigative Dermatology.
Cancer Mar 05, 2012 | not rated yet | 1
A report published this week in the New England Journal of Medicine shows that the 50 percent of metastatic melanoma patients with a specific genetic mutation benefit from the drug Vemurafenib increasing median surviv ...
Cancer Mar 01, 2012 | 5 / 5 (4) | 0
Researchers at Moffitt Cancer Center in Tampa, Fla., and colleagues in California have found that the XL888 inhibitor can prevent resistance to the chemotherapy drug vemurafenib, commonly used for treating patients with melanoma.
Cancer Feb 28, 2012 | not rated yet | 0 |
Investigators from Vanderbilt-Ingram Cancer Center (VICC) and 12 other centers in the United States and Australia have found that a new drug for patients with metastatic melanoma nearly doubled median overall survival.
Cancer Feb 22, 2012 | 5 / 5 (2) | 0 |
Melanoma i/ˌmɛləˈnoʊmə/ (from Greek μέλας - melas, "dark") is a malignant tumor of melanocytes. Melanocytes are cells that produce the dark pigment, melanin, which is responsible for the color of skin. They predominantly occur in skin, but are also found in other parts of the body, including the bowel and the eye (see uveal melanoma). Melanoma can occur in any part of the body that contains melanocytes.
Melanoma is less common than other skin cancers. However, it is much more dangerous and causes the majority (75%) of deaths related to skin cancer. Worldwide, doctors diagnose about 160,000 new cases of melanoma yearly. The diagnosis is more frequent in women than in men and is particularly common among Caucasians living in sunny climates, with high rates of incidence in Australia, New Zealand, North America, Latin America, and northern Europe. According to a WHO report, about 48,000 melanoma related deaths occur worldwide per year.
The treatment includes surgical removal of the tumor, adjuvant treatment, chemo- and immunotherapy, or radiation therapy. The chance of a cure is greatest when the tumor is discovered while it is still small and thin, and can be entirely removed surgically.
This text uses material from Wikipedia and is available under the GNU Free Documentation License.
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