Metastatic Melanoma

AACR: ICMgp100 tolerated, active in advanced melanoma

(HealthDay)—An affinity-enhanced T cell receptor specific for the human leukocyte antigen-A2 restricted melanoma gp 100 peptide fused to an anti-CD3 antibody fragment, IMCgp100, seems promising for advanced ...

Apr 09, 2014
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Killing cancer through the immune system

One of the confounding characteristics of cancer has long been that the body's usually active patrol against viruses tends to leave deadly cancer cells alone to fester, mutate and spread.

Feb 04, 2014
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Team finds new target for melanoma treatment

Scientists at Sanford-Burnham Medical Research Institute (Sanford-Burnham) today announced the discovery that a gene encoding an enzyme, phosphoinositide-dependent kinase-1 (PDK1), plays an essential role in the development ...

Sep 16, 2013
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Scientists identify targets for melanoma immunotherapy

Using a highly sensitive technology called NanoString, researchers have identified seven targets that could potentially be used to develop new immunotherapies for patients with metastatic melanoma, according to a study published ...

Sep 10, 2013
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Latest Spotlight News

Turning off depression in the brain

Scientists have traced vulnerability to depression-like behaviors in mice to out-of-balance electrical activity inside neurons of the brain's reward circuit and experimentally reversed it – but there's ...

Building 'smart' cell-based therapies

A Northwestern University synthetic biology team has created a new technology for modifying human cells to create programmable therapeutics that could travel the body and selectively target cancer and other ...