Myocardial Infarction

No improvements with losmapimod after heart attack

Patients taking losmapimod, an anti-inflammatory drug currently being developed, for 12 weeks following a heart attack did not show improvements in the trial's primary endpoint, the rate of cardiovascular death, subsequent ...

Apr 04, 2016
popularity0 comments 0

ACEI/ARBs up AMI outcomes regardless of renal status

(HealthDay)—For acute myocardial infarction (AMI) survivors, angiotensin-converting enzyme inhibitor (ACEI) and angiotensin receptor blocker (ARB) treatment is associated with improved long-term survival, according to research ...

Apr 08, 2016
popularity0 comments 0

Low BMI and death after heart attack

Low body mass index increases risk mortality after acute myocardial infarction (AMI), even after adjustment for other health factors that affect body weight, according to a study this week in PLOS Medicine. Emily Bucholz, ...

Apr 19, 2016
popularity1 comments 0

Myocardial infarction (MI) or acute myocardial infarction (AMI), commonly known as a heart attack, results from the interruption of blood supply to a part of the heart, causing heart cells to die. This is most commonly due to occlusion (blockage) of a coronary artery following the rupture of a vulnerable atherosclerotic plaque, which is an unstable collection of lipids (cholesterol and fatty acids) and white blood cells (especially macrophages) in the wall of an artery. The resulting ischemia (restriction in blood supply) and ensuing oxygen shortage, if left untreated for a sufficient period of time, can cause damage or death (infarction) of heart muscle tissue (myocardium).

Classical symptoms of acute myocardial infarction include sudden chest pain (typically radiating to the left arm or left side of the neck), shortness of breath, nausea, vomiting, palpitations, sweating, and anxiety (often described as a sense of impending doom). Women may experience fewer typical symptoms than men, most commonly shortness of breath, weakness, a feeling of indigestion, and fatigue. Approximately one-quarter of all myocardial infarctions are "silent", that is without chest pain or other symptoms.

Among the diagnostic tests available to detect heart muscle damage are an electrocardiogram (ECG), echocardiography, cardiac MRI and various blood tests. The most often used blood markers are the creatine kinase-MB (CK-MB) fraction and the troponin levels. Immediate treatment for suspected acute myocardial infarction includes oxygen, aspirin, and sublingual nitroglycerin.

Most cases of STEMI (ST elevation MI) are treated with thrombolysis or percutaneous coronary intervention (PCI). NSTEMI (non-ST elevation MI) should be managed with medication, although PCI is often performed during hospital admission. In people who have multiple blockages and who are relatively stable, or in a few emergency cases, bypass surgery may be an option, especially in diabetics.

Heart attacks are the leading cause of death for both men and women worldwide. Important risk factors are previous cardiovascular disease, older age, tobacco smoking, high blood levels of certain lipids (triglycerides, low-density lipoprotein) and low levels of high density lipoprotein (HDL), diabetes, high blood pressure, obesity, chronic kidney disease, heart failure, excessive alcohol consumption, the abuse of certain drugs (such as cocaine and methamphetamine), and chronic high stress levels.

This text uses material from Wikipedia licensed under CC BY-SA

Latest Spotlight News

Mouse study links heart regeneration to telomere length

Researchers at the Spanish National Center for Cardiovascular Research have discovered that the ends of heart muscle cell chromosomes rapidly erode after birth, limiting the cells' ability to proliferate and replace damaged ...

Development of gut microbes and gut immunity linked

Studying twins from birth through age 2, scientists at Washington University School of Medicine in St. Louis have shown that the gut's immune system develops in sync with the gut's tens of trillions of microbes. The findings ...

Cell phones and rats: Study explores radiation exposure

For some years research teams have explored and attempted to sort out any evidence concerning a cause-effect situation with mobile phones and cancer. Interest in the question does not disappear. Scientific groups prefer to ...

The brain needs cleaning to stay healthy

Research led by the Achucarro Basque Center for Neuroscience, the University of the Basque Country (UPV/EHU), and the Ikerbasque Foundation has revealed the mechanisms that keep the brain clean during neurodegenerative diseases.

Mimicking deep sleep brain activity improves memory

It is not surprising that a good night's sleep improves our ability to remember what we learned during the day. Now, researchers at the RIKEN Brain Science Institute in Japan have discovered a brain circuit that governs how ...