Neurodegeneration
Structural dynamics underlying memory in aging brains
(Medical Xpress)—When the brains of those who have succumbed to age-related neurodegeneration are analyzed post-mortem, they typically show significant atrophy on all scales. Not only is the cortex thinner ...
Neuroscience
Apr 17, 2013 |
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Neuroscientists show 'jumping genes' may contribute to aging-related brain defects
As the body ages, the physical effects are notable; wrinkles in the skin appear, physical exertion becomes harder. But there are also less visible processes going on. Inside aging brains there is another phenomenon at work, ...
Neuroscience
Apr 08, 2013 |
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Genetic markers ID second Alzheimer's pathway
Researchers at Washington University School of Medicine in St. Louis have identified a new set of genetic markers for Alzheimer's that point to a second pathway through which the disease develops.
Alzheimer's disease & dementia
Apr 04, 2013 |
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'RNA sponge' mechanism may cause ALS/FTD neurodegeneration
The most common genetic cause of both ALS (amyotrophic lateral sclerosis) and FTD (frontotemporal dementia) was recently identified as an alteration in the gene C9orf72. But how the mutation causes neurodegenerative disease ...
Genetics
Apr 01, 2013 |
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Possible role for Huntington's gene discovered
About 20 years ago, scientists discovered the gene that causes Huntington's disease, a fatal neurodegenerative disorder that affects about 30,000 Americans. The mutant form of the gene has many extra DNA ...
Genetics
Jan 16, 2013 |
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Researchers uncover toxic interaction in neurons that leads to dementia and ALS
Researchers at Mayo Clinic in Florida have uncovered a toxic cellular process by which a protein that maintains the health of neurons becomes deficient and can lead to dementia. The findings shed new light on the link between ...
Medical research
Dec 10, 2012 |
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Researchers show possible trigger for MS nerve damage
High-resolution real-time images show in mice how nerves may be damaged during the earliest stages of multiple sclerosis. The results suggest that the critical step happens when fibrinogen, a blood-clotting ...
Medical research
Nov 27, 2012 |
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Parkinson's disease protein causes disease spread and neuron death in healthy animals
Understanding how any disease progresses is one of the first and most important steps towards finding treatments to stop it. This has been the case for such brain-degenerating conditions as Alzheimer's disease. ...
Parkinson's & Movement disorders
Nov 15, 2012 |
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Blocking destruction of defective proteins unexpectedly delays neurodegeneration in mice
One might expect that ridding a brain cell of damaged proteins would be a universally good thing, and that impairing the cell's ability to do this would allow the faulty proteins to accumulate within the cell, possibly to ...
Medical research
Aug 15, 2012 |
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Two proteins offer a 'clearer' way to treat Huntington's disease
In a paper published in the July 11 online issue of Science Translational Medicine, researchers at the University of California, San Diego School of Medicine have identified two key regulatory proteins critic ...
Neuroscience
Jul 11, 2012 |
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ApoE4 Alzheimer's gene causes brain's blood vessels to leak, die
Common variants of the ApoE gene are strongly associated with the risk of developing late-onset Alzheimer's disease, but the gene's role in the disease has been unclear. Now, researchers funded by the National ...
Alzheimer's disease & dementia
May 16, 2012 |
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Same genes linked to early- and late-onset Alzheimer's disease
The same gene mutations linked to inherited, early-onset Alzheimer's disease have been found in people with the more common late-onset form of the illness.
Alzheimer's disease & dementia
Feb 01, 2012 |
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Regulatory enzyme overexpression may protect against neurodegeneration in Huntington's disease
Treatment that increases brain levels of an important regulatory enzyme may slow the loss of brain cells that characterizes Huntington's disease (HD) and other neurodegenerative disorders. In a report receiving advance online ...
Neuroscience
Dec 18, 2011 |
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Researchers rebuild the brain's circuitry
Neuron transplants have repaired brain circuitry and substantially normalized function in mice with a brain disorder, an advance indicating that key areas of the mammalian brain are more reparable than was ...
Neuroscience
Nov 24, 2011 |
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Non-coding RNA relocates genes when it's time to go to work
Cells develop and thrive by turning genes on and off as needed in a precise pattern, a process known as regulated gene transcription. In a paper published in the Nov. 9 issue of the Journal of Neuroscience, researchers at the ...
Neuroscience
Nov 10, 2011 |
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Neurodegeneration is the umbrella term for the progressive loss of structure or function of neurons, including death of neurons. Many neurodegenerative diseases including Parkinson’s, Alzheimer’s, and Huntington’s occur as a result of neurodegenerative processes. As research progresses, many similarities appear which relate these diseases to one another on a sub-cellular level. Discovering these similarities offers hope for therapeutic advances that could ameliorate many diseases simultaneously. There are many parallels between different neurodegenerative disorders including atypical protein assemblies as well as induced cell death. Neurodegeneration can be found in many different levels of neuronal circuitry ranging from molecular to systemic.
This text uses material from Wikipedia and is available under the GNU Free Documentation License.
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