While pain and fear are very different experiences, past studies showed that they can sometimes be closely related to one another. For instance, when many animals and humans are in dangerous or life-threatening situations, ...
A new approach to treating neuropathic pain is making a key step forward thanks to researchers at The University of Texas at Austin.
Jan 30, 2024
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In the midst of a global opioid epidemic, a team of scientists is exploring natural killer (NK) cells as an alternative treatment for neuropathic pain. In an Opinion piece published June 27th in the journal Trends in Neurosciences, ...
Jun 27, 2023
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For the first time, researchers have recorded pain-related data from inside the brain of individuals with chronic pain disorders caused by stroke or amputation (phantom limb pain). A long sought-after goal has been to understand ...
May 22, 2023
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Neuropathic pain—abnormal hypersensitivity to stimuli—is associated with impaired quality of life and is often poorly managed. Estimates suggest that 3% to 17% of adults suffer from neuropathic pain, including a quarter ...
May 4, 2023
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Many people are unaware that some antidepressants (medications used to treat people living with depression) are also being prescribed to treat certain chronic pain conditions.
Feb 1, 2023
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A combination of chemotherapy and drugs that stimulate the immune system to combat cancer is increasingly used to control progression of the disease in patients. On the other hand, clinical studies show that the combination ...
Jan 30, 2023
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Northwestern Medicine investigators have discovered that specific calcium channels help regulate sex differences in the functioning of immune cells for neuroinflammation and overall neuropathic pain, according to findings ...
Jan 30, 2023
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Neuropathic pain is a type of chronic pain caused by damage to the nervous system due mainly to metabolic diseases such as diabetes and arthritis, or the side effects of some kinds of chemotherapy. It is believed to affect ...
Jan 10, 2023
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Due to their high efficacy, opioids are used widely for the management of neuropathic pain, despite the increasing rates of opioid addiction and deaths due to overdose. To avoid these side effects, there is an urgent need ...
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Neuropathic pain results from lesions or diseases affecting the somatosensory system. It may be associated with abnormal sensations called dysesthesia, which occur spontaneously and allodynia that occurs in response to external stimuli. Neuropathic pain may have continuous and/or episodic (paroxysmal) components. The latter are likened to an electric shock. Common qualities include burning or coldness, "pins and needles" sensations, numbness and itching. Nociceptive pain, by contrast, is more commonly described as aching.
Up to 7% to 8% of the European population is affected and in 5% of persons it may be severe. Neuropathic pain may result from disorders of the peripheral nervous system or the central nervous system (brain and spinal cord). Thus, neuropathic pain may be divided into peripheral neuropathic pain, central neuropathic pain, or mixed (peripheral and central) neuropathic pain.
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