Osteoarthritis

How cartilage cells sense forceful injury

We live with the same cartilage—the tissue that connects our joints—for a lifetime. And since we can't readily make new cartilage cells, we had better figure out how to keep what we have healthy.

Nov 10, 2014
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The 'ultimate' stem cell

In the earliest moments of a mammal's life, the developing ball of cells formed shortly after fertilisation 'does as mother says' – it follows a course that has been pre-programmed in the egg by the mother. ...

Oct 30, 2014
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More involvement needed in models of care

Clinicians and health administrators need to take a more active role in implementing and evaluating models of care (MoCs) for musculosketal health, according to a recent study.

Oct 01, 2014
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Osteoarthritis (OA) also known as degenerative arthritis or degenerative joint disease or osteoarthrosis, is a group of mechanical abnormalities involving degradation of joints, including articular cartilage and subchondral bone. Symptoms may include joint pain, tenderness, stiffness, locking, and sometimes an effusion. A variety of causes—hereditary, developmental, metabolic, and mechanical—may initiate processes leading to loss of cartilage. When bone surfaces become less well protected by cartilage, bone may be exposed and damaged. As a result of decreased movement secondary to pain, regional muscles may atrophy, and ligaments may become more lax.

Treatment generally involves a combination of exercise, lifestyle modification, and analgesics. If pain becomes debilitating, joint replacement surgery may be used to improve the quality of life. OA is the most common form of arthritis, and the leading cause of chronic disability in the United States. It affects about 8 million people in the United Kingdom and nearly 27 million people in the United States.

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