Pain

Scientists discover molecule triggers sensation of itch

Scientists at the National Institutes of Health report they have discovered in mouse studies that a small molecule released in the spinal cord triggers a process that is later experienced in the brain as ...

Medical research created May 23, 2013 | popularity 5 / 5 (3) | comments 0 | with audio podcast

Restless legs syndrome, insomnia and brain chemistry: A tangled mystery solved?

Johns Hopkins researchers believe they may have discovered an explanation for the sleepless nights associated with restless legs syndrome (RLS), a symptom that persists even when the disruptive, overwhelming nocturnal urge ...

Neuroscience created May 07, 2013 | popularity 4.4 / 5 (5) | comments 1 | with audio podcast

Heroin vaccine blocks relapse in preclinical study

Scientists at The Scripps Research Institute (TSRI) have reported successful preclinical tests of a new vaccine against heroin. The vaccine targets heroin and its psychoactive breakdown products in the bloodstream, preventing ...

Medical research created May 06, 2013 | popularity 5 / 5 (3) | comments 0 | with audio podcast

Genetic mutation linked with typical form of migraine

A research team led by a Howard Hughes Medical Institute investigator at the University of California, San Francisco has identified a genetic mutation that is strongly associated with a typical form of migraine.

Genetics created May 01, 2013 | popularity 4.5 / 5 (2) | comments 1 | with audio podcast

Study identifies key shift in the brain that creates drive to overeat

A team of American and Italian neuroscientists has identified a cellular change in the brain that accompanies obesity. The findings could explain the body's tendency to maintain undesirable weight levels, rather than an ideal ...

Medical research created Apr 29, 2013 | popularity 5 / 5 (4) | comments 0 | with audio podcast

Researchers identify first drug targets in childhood genetic tumor disorder

Two mutations central to the development of infantile myofibromatosis (IM)—a disorder characterized by multiple tumors involving the skin, bone, and soft tissue—may provide new therapeutic targets, according to researchers ...

Genetics created 11 hours ago | popularity 3 / 5 (2) | comments 0 | with audio podcast

Having both migraines, depression may mean smaller brain

(HealthDay)—Migraines and depression can each cause a great deal of suffering, but new research indicates the combination of the two may be linked to something else entirely—a smaller brain.

Neuroscience created May 22, 2013 | popularity 4 / 5 (4) | comments 2 | with audio podcast

Study says empathy plays a key role in moral judgments

Is it permissible to harm one to save many? Those who tend to say "yes" when faced with this classic dilemma are likely to be deficient in a specific kind of empathy, according to a report published in the scientific journal ...

Psychology & Psychiatry created May 22, 2013 | popularity not rated yet | comments 2 | with audio podcast

Finding a family for a pair of orphan receptors in the brain

Researchers at Emory University have identified a protein that stimulates a pair of "orphan receptors" found in the brain, solving a long-standing biological puzzle and possibly leading to future treatments for neurological ...

Medical research created May 21, 2013 | popularity 5 / 5 (2) | comments 0 | with audio podcast

Sugar injections for knee arthritis may ease pain

(HealthDay)—Injections of a sugar solution appear to help relieve knee pain and stiffness related to osteoarthritis, a new study suggests.

Arthritis & Rheumatism created May 21, 2013 | popularity 4.5 / 5 (2) | comments 0 | with audio podcast

Music therapy reduces anxiety, use of sedatives for patients receiving ventilator support

New research suggests that for some hospitalized ICU patients on mechanical ventilators, using headphones to listen to their favorite types of music could lower anxiety and reduce their need for sedative medications.

Psychology & Psychiatry created May 20, 2013 | popularity not rated yet | comments 0 | with audio podcast

New theory on genesis of osteoarthritis comes with successful therapy in mice

Scientists at Johns Hopkins have turned their view of osteoarthritis (OA) inside out. Literally. Instead of seeing the painful degenerative disease as a problem primarily of the cartilage that cushions joints, ...

Arthritis & Rheumatism created May 19, 2013 | popularity 4.9 / 5 (8) | comments 0 | with audio podcast

For combat veterans suffering from post-traumatic stress disorder, 'fear circuitry' in the brain never rests

Chronic trauma can inflict lasting damage to brain regions associated with fear and anxiety. Previous imaging studies of people with post-traumatic stress disorder, or PTSD, have shown that these brain regions can over-or ...

Neuroscience created May 18, 2013 | popularity 5 / 5 (1) | comments 0 | with audio podcast

Little evidence for prediction rules for low back pain

(HealthDay)—Few randomized clinical trials have been done to assess clinical prediction rules for patients with lower back pain, and the trials that have been done are of low quality and do not provide ...

Diseases, Conditions, Syndromes created May 17, 2013 | popularity not rated yet | comments 0 | with audio podcast

How serotonin receptors can shape drug effects, from LSD to migraine medication

New findings by researchers carrying out experiments at the U.S. Department of Energy Office of Science's Advanced Photon Source (APS) help explain why some drugs that interact with two kinds of human serotonin ...

Medical research created May 17, 2013 | popularity 4 / 5 (1) | comments 0 | with audio podcast


Pain is an unpleasant sensation often caused by intense or damaging stimuli such as stubbing a toe, burning a finger, putting alcohol on a cut, and bumping the "funny bone." The International Association for the Study of Pain has a definition that is widely used: "Pain is an unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage".

Pain motivates the individual to withdraw from damaging situations, to protect a damaged body part while it heals, and to avoid similar experiences in the future. Most pain resolves promptly once the painful stimulus is removed and the body has healed, but sometimes pain persists despite removal of the stimulus and apparent healing of the body; and sometimes pain arises in the absence of any detectable stimulus, damage or disease.

Pain is the most common reason for physician consultation in the United States. It is a major symptom in many medical conditions, and can significantly interfere with a person's quality of life and general functioning. Psychological factors such as social support, hypnotic suggestion, excitement, or distraction can significantly modulate pain's intensity or unpleasantness.

This text uses material from Wikipedia and is available under the GNU Free Documentation License.

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