Medical research

New models advance the study of deadly human prion diseases

By directly manipulating a portion of the prion protein-coding gene, Whitehead Institute researchers have created mouse models of two neurodegenerative diseases that are fatal in humans. The highly accurate reproduction of ...

Medical research

Lab mice breakthrough offers Alzheimer's hope (Update)

Scientists on Thursday said they had tested a drug that in mice prevented the death of brain cells, boosting hopes in the fight against Alzheimer's, Parkinson's and other neurodegenerative diseases.

Genetics

Study finds two gene classes linked to new prion formation

Unlocking the mechanisms that cause neurodegenerative prion diseases may require a genetic key, suggest new findings reported by University of Illinois at Chicago distinguished professor of biological sciences Susan Liebman.

Neuroscience

Fertility and prion disease

A high degree of uncertainty surrounds the issue of the prion disease risk associated with fertility drugs derived from urine, gonadotropins. Writing in the International Journal of Risk Assessment and Management, a team ...

Parkinson's & Movement disorders

Untangling fibril formation and dissociation in Parkinson's disease

Prions are misfolded proteins. The complex three-dimensional structure of a prion's progenitor protein becomes altered, somehow causing it to malfunction. Worse, the malformation of these progenitor proteins into prions causes ...

Diseases, Conditions, Syndromes

Medical researchers discover hidden side of prion diseases

Medical researchers in Canada and the United States recently published their joint findings that fatal prion diseases, which include BSE or "mad cow disease," have a hidden signature.

Medical research

Finding a way forward in the fight against prion disease

For much of her adult life Valerie Sim has been fascinated by a disease very few in the world can claim to even begin to understand. Sim is one of Canada's foremost authorities on prion disease—more commonly known as bovine ...

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