A team at Cold Spring Harbor Laboratory (CSHL) has developed a strikingly new approach for treating Rett syndrome, a devastating autism spectrum disorder (ASD) that affects 1 in 10,000 people in the US, mostly girls. In a ...
Jul 27, 2015
0
648
People with Rett Syndrome, a rare and debilitating neurodevelopmental disorder, exhibit many autism-like traits. Now researchers at MIT have identified a protein that plays an important role in the disorder. The researchers ...
Jul 25, 2016
0
900
A paper published online today in Nature reveals that glia play a key role in preventing the progression of the most prominent Rett Syndrome symptoms displayed by mouse models of the disease: lethality, irregular breathing ...
Jun 29, 2011
0
0
Penn State University scientists have discovered a novel drug target and have rescued functional deficits in human nerve cells derived from patients with Rett Syndrome, a severe form of autism-spectrum disorder. The research, ...
Jan 4, 2016
0
125
Researchers have made a breakthrough genetic discovery into the cause of a spectrum of severe neurological conditions.
Oct 8, 2020
0
153
Researchers at the University of Alabama at Birmingham are part of the international STARS study to see if a drug originally developed for Parkinson's disease might help reduce breathing issues common in patients with Rett ...
Dec 19, 2016
0
364
Using an innovative microscopy method, scientists at The Picower Institute for Learning and Memory at MIT observed how newborn neurons struggle to reach their proper places in advanced human brain tissue models of Rett syndrome, ...
Jul 29, 2022
0
94
The immune system is designed to protect us from disease. But what if it was malfunctioning? Would it make a disease worse? That appears to be the case with Rett syndrome, a neurodevelopmental disorder, and possibly in other ...
Apr 21, 2015
0
526
Researchers have uncovered 30 genes that could, one day, serve as therapeutic targets to reverse Rett syndrome, a rare neurological disorder that affects only girls and is a severe form of an autism spectrum disorder.
Jan 30, 2017
0
88
A Massachusetts General Hospital (MGH) research team has developed a new female mouse model for the neurodevelopmental disorder Rett syndrome and in the process found evidence that relieving symptoms of the genetic disorder ...
Jul 23, 2018
0
138
Rett syndrome is a neurodevelopmental disorder of the grey matter of the brain that almost exclusively affects females. The clinical features include small hands and feet and a deceleration of the rate of head growth (including microcephaly in some). Repetitive hand movements, such as wringing and/or repeatedly putting hands into the mouth, are also noted. People with Rett syndrome are prone to gastrointestinal disorders and up to 80% have seizures. They typically have no verbal skills, and about 50% of individuals affected are not ambulatory. Scoliosis, growth failure, and constipation are very common and can be problematic.
The signs of this disorder are most easily confused with those of Angelman syndrome, cerebral palsy and autism.
Some argue[citation needed] that it is misclassified as an autism spectrum disorder, just as it would be to include such disorders as fragile X syndrome, tuberous sclerosis, or Down syndrome where one can see autistic features. However, it has been suggested that it be removed from the DSM-5, because it has a specific etiology.
It was first described by Austrian pediatrician Andreas Rett in 1966.
In DSM-IV-TR page 76, Rett's Disorder 299.80 is listed under the broad category of Pervasive Developmental Disorders.
This text uses material from Wikipedia licensed under CC BY-SA
