Spinal Muscular Atrophy
A protein that has shown early promise in preventing the loss of muscle function in mouse models of Duchenne muscular dystrophy, has been found in a new study to be a key player in the process of joining nerves ...
Neuroscience Feb 14, 2012 | 5 / 5 (3) | 1 |
Antisense oligonucleotides short segments of genetic material designed to target specific areas of a gene or chromosome that activated an enzyme to "chew up" toxic RNA (ribonucleic acid) could point the way ...
Genetics Feb 27, 2012 | not rated yet | 0 |
Researchers at UCLA have been searching for the cause of a rare disease that virtually no one has ever heard: PCH1, or pontocerebellar hypoplasia type 1, which attacks the brain and the spine.
Genetics Apr 30, 2012 | 5 / 5 (2) | 0 |
(Medical Xpress) -- An abnormally low level of a protein in certain nerve cells is linked to movement problems that characterize the deadly childhood disorder spinal muscular atrophy, new research in animals suggests.
Neuroscience Apr 11, 2012 | not rated yet | 0 |
In an effort to identify the underlying causes of neurological disorders that impair motor functions such as walking and breathing, UCLA researchers have developed a novel system to measure the communication between stem ...
Neuroscience May 05, 2012 | 5 / 5 (3) | 0 |
A new study from Cold Spring Harbor Laboratory (CSHL) reports surprising results that suggest that the devastating neuromuscular disease, spinal muscular atrophy (SMA), might not exclusively affect the motor neurons in the ...
Medical research Oct 05, 2011 | not rated yet | 0 |
A step forward toward muscular dystrophy treatment: 'Antisense' compound rids muscle cells of toxic RNA
Scientists have reversed symptoms of myotonic muscular dystrophy in mice by eliminating a buildup of toxic RNA in muscle cells. The work, carried out by scientists at the University of Rochester Medical Center, Isis Pharmaceuticals ...
Medical research Aug 01, 2012 | 4 / 5 (2) | 0 |
An innovative strategy for regenerating skeletal muscle tissue using cells derived from the amniotic fluid is outlined in new research published by scientists at the UCL Institute of Child Health.
Medical research Jun 01, 2012 | not rated yet | 0 |
The Allen Institute for Brain Science announced today the discovery of a new class of cells in the spinal cord that act like neural stem cells, offering a fresh avenue in the search for therapies to treat spinal cord injury ...
Medical research Sep 15, 2011 | 5 / 5 (7) | 0 |
Structure that edits messenger RNA transcripts defective in two different forms of motor neuron diseases
Amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA) are degenerative motor neuron diseases in which the key mutated genes are involved in RNA metabolism. This similarity suggests that a ...
Medical research Apr 26, 2013 | 5 / 5 (1) | 0
A University of Connecticut researcher is advancing the understanding of the devastating inherited condition known as spinal muscular atrophy.
Neuroscience Jan 29, 2013 | 5 / 5 (1) | 0
Investigators at Nationwide Children's Hospital may have discovered a biological explanation for why low levels of oxygen advance spinal muscular atrophy (SMA) symptoms and why breathing treatments help SMA patients live ...
Genetics Aug 21, 2012 | not rated yet | 0 |
(HealthDay)—Surgery for patients with early-onset scoliosis is associated with an 18 percent mortality rate and an 84 percent complication rate, according to research published in the Feb. 15 issue of Spine.
Surgery Mar 25, 2013 | not rated yet | 0
A study by scientists from the Motor Neuron Center at Columbia University Medical Center (CUMC) suggests that spinal muscular atrophy (SMA), a genetic neuromuscular disease in infants and children, results ...
Medical research Oct 11, 2012 | 5 / 5 (1) | 0 |
Spinal muscular atrophy is a debilitating neuromuscular disease that in its most severe form is the leading genetic cause of infant death. By experimenting with an ALS drug in two very different animal models, researchers ...
Neuroscience Apr 09, 2013 | not rated yet | 0 |
Spinal muscular atrophy (SMA) is an incurable autosomal recessive disease caused by a genetic defect in the SMN1 gene which codes SMN, a protein necessary for survival of motor neurons, and resulting in death of neuronal cells in the anterior horn of spinal cord and subsequent system-wide muscle wasting (atrophy).
Spinal muscular atrophy manifests in various degrees of severity which all have in common general muscle wasting and mobility impairment. Other body systems may be affected as well, particularly in early-onset forms. Spinal muscular atrophy is the most common genetic cause of infant death.
Sometimes, the term spinal muscular atrophy is used to encompass other hereditary disorders that involve death of motor neurons in the anterior horn of spinal cord - see spinal muscular atrophies.
This text uses material from Wikipedia and is available under the GNU Free Documentation License.
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