American Journal of Pathology
The American Journal of Pathology is the official academic journal of the American Society for Investigative Pathology, covering original papers in disease biology, particularly in human disease.
New study pinpoints biochemical mechanism underlying fibrosis following glaucoma surgery
The most common cause of failure after glaucoma surgery is scarring at the surgical site, so researchers are actively looking for ways to minimize or prevent scar formation. Previous work had suggested that vascular endothelial ...
Ophthalmology
May 17, 2013 |
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Amplification of a Stat5 gene produces excess oncogenic protein that drives prostate cancer spread
An international group of investigators, led by researchers at Thomas Jefferson University's Kimmel Cancer Center, have solved the mystery of why a substantial percentage of castrate-resistant metastatic prostate cancer cells ...
Cancer
May 07, 2013 |
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Cell-permeable peptide shows promise for controlling cardiovascular disease
Atherosclerosis – sometimes called "hardening of the arteries" – is a leading cause of death and morbidity in Western countries. A cell-permeable peptide containing the NF-kB nuclear localization sequence (NLS) shows ...
Cardiology
Apr 17, 2013 |
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Ranibizumab may prevent retinal detachment side effect
Proliferative vitreoretinopathy (PVR), or the formation of scar tissue in the eye, is a serious, sight-threatening complication in people recovering from surgical repair of retinal detachment. PVR is difficult to predict, ...
Ophthalmology
Apr 09, 2013 |
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Study points to essential role of IL-22 in lung repair after the flu
Once the initial episode of influenza has passed, the chronic effects tend to be overlooked. The results of a new study indicate that the cytokine interleukin-22 (IL-22) plays a critical role in normal lung repair following ...
Medical research
Mar 11, 2013 |
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Activation of cortical type 2 cannabinoid receptors ameliorates ischemic brain injury
A new study published in the March issue of The American Journal of Pathology suggests that cortical type 2 cannabinoid (CB2) receptors might serve as potential therapeutic targets for cerebral ischemia.
Medical research
Feb 21, 2013 |
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Tamoxifen ameliorates symptoms of Duchenne muscular dystrophy
A new study has found that tamoxifen, a well-known breast cancer drug, can counteract some pathologic features in a mouse model of Duchenne muscular dystrophy (DMD). At present, no treatment is known to produce ...
Diseases, Conditions, Syndromes
Jan 15, 2013 |
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Previously unknown mechanism identified in oncogene-induced senescence
Cell aging, or cellular senescence, has an important role in the natural physiological response to tumor development. Activated oncogenes are able to induce senescence, and recent findings have suggested that oncogene-induced ...
Cancer
Dec 12, 2012 |
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Researchers identify gene involved in lung tumor growth
Lung cancer researchers at St. Joseph's Hospital and Medical Center in Phoenix, Ariz., in collaboration with researchers at the Translational Genomics Research Institute and other institutions, have identified a gene that ...
Cancer
Nov 29, 2012 |
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Topical simvastatin shown to accelerate wound healing in diabetes
Delayed wound healing is a major complication of diabetes because the physiological changes in tissues and cells impair the wound healing process. This can result in additional disease outcomes such as diabetic foot ulcer, ...
Diabetes
Nov 27, 2012 |
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Researchers implicate well-known protein in fibrosis
An international multi-disciplinary research team led by Northwestern Medicine scientists has uncovered a new role for the protein toll-like receptor 4 (TLR4) in the development of tissue fibrosis, or scarring.
Medical research
Nov 20, 2012 |
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Sweat glands play major role in healing human wounds, research shows
Turns out the same glands that make you sweat are responsible for another job vital to your health: they help heal wounds.
Medical research
Nov 20, 2012 |
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New study sheds new light on the progression and invasiveness of ductal breast cancer
Ductal carcinoma in situ (DCIS) is considered a precursor lesion for invasive breast cancer if untreated, and is found in approximately 45% of patients with invasive ductal carcinoma (IDC). Patients with DCIS only (not accompanied ...
Cancer
Oct 16, 2012 |
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Adult stem cells change their epigenome to generate new organs
A study developed by researchers at the IDIBELL, led by Manel Esteller, has identified epigenetic changes that occur in adult stem cells to generate different tissues of the human body.
Medical research
Oct 02, 2012 |
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Two gene mutations drive adrenal cancer
Two different genetic mutations cooperate to induce adrenal cancer, according to a new study from researchers at the University of Michigan Comprehensive Cancer Center and University of Sao Paulo in Brazil.
Cancer
Sep 10, 2012 |
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