Cancer Discovery
Researchers find possible 'master switch' in deadly brain cancer
(Medical Xpress)—Researchers at the University of Virginia School of Medicine have identified a promising target for treating glioblastoma, one that appears to avoid many of the obstacles that typically frustrate efforts ...
Cancer
13 hours ago |
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Changing cancer's environment to halt its spread
By studying the roles two proteins, thrombospondin-1 and prosaposin, play in discouraging cancer metastasis, a trans-Atlantic research team has identified a five-amino acid fragment of prosaposin that significantly reduces ...
Cancer
May 21, 2013 |
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How some cancers 'poison the soil' to block metastasis
Cancer spread or metastasis can strike unprecedented fear in the minds of cancer patients. The "seed and the soil" hypothesis proposed by Stephen Paget in 1889 is now widely accepted to explain how cancer cells (seeds) are ...
Cancer
Apr 30, 2013 |
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MicroRNAs can convert normal cells into cancer promoters
Unraveling the mechanism that ovarian cancer cells use to change normal cells around them into cells that promote tumor growth has identified several new targets for treatment of this deadly disease.
Cancer
Nov 21, 2012 |
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Early results show two drugs may be better than one to treat most deadly skin cancer
Adding lung cancer drugs to targeted melanoma treatment could increase survival for certain patients, according to research published in Cancer Discovery today.
Cancer
Feb 12, 2013 |
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Scientists find a new way to boost common cancer drugs
Shutting down a specific pathway in cancer cells appears to improve the ability of common drugs to wipe those cells out, according to new research from scientists at Fox Chase Cancer Center, published in the January issue ...
Cancer
Jan 14, 2013 |
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Study finds potential to match tumors with known cancer drugs
When it comes to gene sequencing and personalized medicine for cancer, spotting an aberrant kinase is a home run. The proteins are relatively easy to target with drugs and plenty of kinase inhibitors already exist.
Cancer
Feb 05, 2013 |
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Research on immune-cell therapy could strengthen promising melanoma treatment
A new study of genetically modified immune cells by scientists from UCLA and the California Institute of Technology could help improve a promising treatment for melanoma, an often fatal form of skin cancer.
Cancer
Mar 22, 2013 |
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Epigenetic causes of prostate cancer
(Medical Xpress)—In about half of all prostate tumours, there are two genetic areas that are fused with one another. When this is not the case, the exact way cancer cells originate in prostate tumours was not clear until ...
Cancer
Sep 05, 2012 |
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Emerging cancer drugs may drive bone tumors
Cancer drugs should kill tumors, not encourage their spread. But new evidence suggests that an otherwise promising class of drugs may actually increase the risk of tumors spreading to bone, according to researchers ...
Cancer
Feb 13, 2013 |
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Genetic vulnerability of lung cancer to lay foundation for new drug options
Physician-researchers at UT Southwestern Medical Center have identified a vulnerability of certain lung-cancer cells – a specific genetic weakness that can be exploited for new therapies.
Cancer
Apr 04, 2013 |
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Novel therapeutic targets identified for small cell lung cancer
Newly discovered molecular differences between small cell lung cancer and nonsmall cell lung cancer have revealed PARP1 and EZH2 as potential therapeutic targets for patients with small cell lung cancer, according to the ...
Cancer
Sep 06, 2012 |
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Doubling up on advanced prostate cancer with PARP inhibitors
A newly discovered function of PARP-1 could be the key to more effective therapeutics to treat advanced prostate cancer patients, a recent preclinical study published in Cancer Discovery by Jefferson's Kimmel ...
Cancer
Oct 09, 2012 |
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PI3-kinase and PARP inhibitor combo may offer new treatment option for triple-neg breast cancers
The simultaneous inhibition of two separate and seemingly unrelated pathways could potentially provide an effective treatment for women with triple-negative breast cancer, according to results of two studies published in ...
Cancer
Nov 12, 2012 |
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Ganetespib shows potency against ALK-positive lung cancer and overcomes crizotinib resistance
A drug that indirectly impairs the function of several cancer-driving proteins, including anaplastic lymphoma kinase (ALK), may be an effective new treatment for patients with ALK—positive non-small cell lung cancer.
Cancer
Mar 26, 2013 |
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