Genetics
Unlocking a secret of stem cell stability
Proper embryonic development depends on a signaling pathway that helps to preserve stem cell "immaturity."
Nov 6, 2013
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1
Genes & Development
Immunology
Inflammation can lead to circadian sleep disorders
Inflammation, which is the root cause of autoimmune disorders including arthritis, Type 1 diabetes, irritable bowel syndrome and Crohn's disease, has unexpected effects on body clock function and can lead to sleep and shiftwork-type ...
Oct 31, 2018
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9
Oncology & Cancer
Study reveals even transient chromosomal errors can initiate cancer
A Ludwig Cancer Research study has found that inducing random chromosome instability (CIN) events in mice for as little as one week is enough to trigger harmful chromosomal patterns in cells that spur the formation of tumors.
Jul 16, 2021
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34
Genetics
Getting straight to the heart of the matter in stem cells
The process by which embryonic stem cells develop into heart cells is a complex process involving the precisely timed activation of several molecular pathways and at least 200 genes. Now, Salk Institute scientists have found ...
Dec 21, 2017
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64
Genetics
Heart disease, leukemia linked to dysfunction in nucleus
We put things into a container to keep them organized and safe. In cells, the nucleus has a similar role: keeping DNA protected and intact within an enveloping membrane. But a new study by Salk Institute scientists, detailed ...
Nov 2, 2016
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73
Genetics
Two genes help older brain gain new cells
Two genes act as molecular midwives to the birth of neurons in adult mammals and when inactivated in mice cause symptoms of Fragile X Syndrome, a major cause of mental retardation, a new Yale University study has shown.
Aug 10, 2017
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5
Genetics
Researchers identify another piece of the 'histone code' puzzle
(Medical Xpress)—DNA is often called the blueprint of life, but the four-letter combinations that make up the genetic code are just part of the story. Built upon the DNA lies additional epigenetic information in the form ...
Jun 11, 2013
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Genetics
A deep dive into cellular aging
Scientists at Sanford Burnham Prebys Medical Discovery Institute and Harvard University have discovered that mitochondria trigger senescence, the sleep-like state of aged cells, through communication with the cell's nucleus—and ...
Feb 20, 2020
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30
Immunology
Newfound mechanism may yield ways to counter mistaken immune attack on body
A newfound genetic regulatory mechanism may shape the immune system's ability to fight viral infections, and play a key role in autoimmune diseases that occur when immune cells attack bodily tissues.
Nov 27, 2018
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112
Medical research
An epigenetic cause of miscarriages is identified and cured in mice
Researchers led by Azusa Inoue at the RIKEN Center for Integrative Medical Sciences (IMS) in Japan have discovered a gene responsible for prenatal death when critical transgenerational instructions are missing from egg cells. ...
Apr 27, 2022
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