Journal of Biological Chemistry

Cardiology

Supertrafficking ion channel found to be arrhythmia culprit

The potassium channel KCNQ1 plays a critical role in the cardiac action potential—the electrical activity underlying heart muscle contraction. Inherited mutations resulting in loss of channel function or gain of function ...

Oncology & Cancer

Cholesterol starvation kills lymphoma cells

Scientists at Northwestern Medicine have developed a novel therapy to trick cancer cells into gobbling up what they think is their favorite food—cholesterol—which actually triggers their destruction. What appears to them ...

Medical research

Large transporter protein linked to schizophrenia

Scientists have suspected mutations in a cellular cholesterol transport protein are associated with psychiatric disorders, but have found it difficult to prove this and to pinpoint how it happens. Now, Kazumitsu Ueda of Kyoto ...

Medical research

Discovery illuminates how cell growth pathway responds to signals

A basic science discovery by researchers at the Johns Hopkins Bloomberg School of Public Health reveals a fundamental way cells interpret signals from their environment and may eventually pave the way for potential new therapies.

HIV & AIDS

Developing effective vaccines against SARS-CoV-2 and HIV

Researchers led by Raghavan Varadarajan, professor at the Molecular Biophysics Unit, Indian Institute of Science (IISc), are working toward developing effective vaccine strategies against two viruses: SARS-CoV-2 and HIV.

Cardiology

Researchers identify biomarker for cardiovascular diseases

The role of the enzyme dipeptidyl peptidase 3 in the blood pressure-regulating renin-angiotensin system was investigated in the inter-university cooperation project BioTechMed-Graz. The results could pave the way for new ...

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