Journal of Biological Chemistry

Medical research

A new contributor to atherosclerosis

Free radicals produced during oxidative stress react with membrane fatty acids to yield highly reactive lipid aldehydes, which can modify proteins and cause cellular or tissue damage.

Medical research

AQAMAN takes aim at rare neurodegenerative diseases

A synthetic small molecule compound called AQAMAN can prevent and even reverse harmful protein build-up in neurons that is associated with several rare neurodegenerative disorders, including polyglutamine (or polyQ) diseases.

Medical research

Early prevention of neuropathic pain

An unpleasant tingling in the hands and feet, numbness, fuzzy and burning sensations—these symptoms may indicate a neuropathy, a disease of the nervous system. If the pain persists for several months, it is referred to ...

Immunology

Early immune response may improve cancer immunotherapies

In a paper published in the Journal of Biological Chemistry, University of Illinois at Chicago researchers and colleagues report a new mechanism for detecting foreign material during early immune responses.

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