Journal of Clinical Investigation

Genetics

New genetic mutation behind childhood glaucoma identified

An international team of scientists led by Mass Eye and Ear, a member of Mass General Brigham, and Boston Children's Hospital, has discovered a new genetic mutation that may be a root cause of severe cases of childhood glaucoma, ...

Oncology & Cancer

Discovery suggests new way to target mantle cell lymphoma

A form of blood cancer known as mantle cell lymphoma is critically dependent on a protein that coordinates gene expression, such that blocking its activity with an experimental drug dramatically slows the growth of this lymphoma ...

Immunology

Study uncovers mechanism behind primary graft dysfunction

Northwestern Medicine scientists have discovered the pathways through which autoantibodies—immune proteins that mistakenly attack a person's own body—leak out of blood vessels and cause primary graft dysfunction in some ...

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