Journal of Clinical Investigation
Drugs limiting excess mucus could save lives
Respiratory conditions that restrict breathing such as asthma and chronic obstructive pulmonary disease (COPD) are common killers worldwide. But no effective treatments exist to address the major cause of ...
Diseases, Conditions, Syndromes
Nov 26, 2012 |
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Seizures linked to surgery drugs can be prevented by anesthetics, study finds (Update)
Two drugs commonly given during cardiac surgery can lead to convulsive seizures, but anesthetics can help cut the risk, according to new research from the Faculty of Medicine at the University of Toronto.
Neuroscience
Nov 26, 2012 |
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Pathway identified in human lymphoma points way to new blood cancer treatments
A pathway called the "Unfolded Protein Response," or UPR, a cell's way of responding to unfolded and misfolded proteins, helps tumor cells escape programmed cell death during the development of lymphoma.
Cancer
Nov 21, 2012 |
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Multiple sclerosis 'immune exchange' between brain and blood is uncovered
DNA sequences obtained from a handful of patients with multiple sclerosis at the University of California, San Francisco (UCSF) Medical Center have revealed the existence of an "immune exchange" that allows the disease-causing ...
Medical research
Nov 19, 2012 |
5 / 5 (2) |
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Genetic factor holds key to blood vessel health
Researchers at Case Western Reserve University School of Medicine have identified a genetic factor that prevents blockages from forming in blood vessels, a discovery that could lead to new therapies for cardiovascular diseases.
Medical research
Nov 19, 2012 |
5 / 5 (1) |
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A code of silence in acute myeloid leukemia
The development of acute myeloid leukemia (AML) is associated with a variety of genetic changes. Some of these alterations are epigenetic, wherein the sequence of the genes is unchanged, but chemical modifications to the ...
Cancer
Nov 19, 2012 |
5 / 5 (1) |
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Immune cell migration is impeded in Huntington's disease
Huntington disease (HD) is an incurable neurodegenerative disease caused by a mutation in the huntingtin gene (htt). Though most of the symptoms of HD are neurological, the mutant HTT protein is expressed in non-neural cells ...
Diseases, Conditions, Syndromes
Nov 19, 2012 |
5 / 5 (1) |
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Can the addition of radiolabeled treatments improve outcomes in advanced metastatic disease?
Radiolabeled agents are powerful tools for targeting and killing cancer cells and may help improve outcomes and lengthen survival times of patients with advanced disease that has spread beyond the initial ...
Cancer
Nov 13, 2012 |
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Home field advantage: Intravaginal immunization may help protect against infection
Sexually-transmitted diseases (STDs) enter the body through the mucosal epithelial cells and the ability to direct pathogen-clearing T-cells to points of infection may be the critical element in developing successful vaccines ...
Immunology
Nov 12, 2012 |
5 / 5 (1) |
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HIV-1 vaccine development: Pinning down a moving target
HIV-1 is a genetically diverse collection of viruses, making it a moving target in vaccine development.
HIV & AIDS
Nov 12, 2012 |
5 / 5 (1) |
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Study justifies L-DOPA therapy for Angelman syndrome
Last year a clinical trial of L-DOPA—a mainstay of Parkinson's disease therapy—was launched for Angelman syndrome, a rare intellectual disorder that shares similar motor symptoms such as tremors and difficulty ...
Medical research
Nov 12, 2012 |
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New findings on gene regulation and bone development
The patients have single short fingers (metacarpals) and toes (metatarsals) and can be restricted in growth due to a shortened skeleton. This hereditary disease is called brachydactyly type E (Greek for short ...
Genetics
Nov 05, 2012 |
5 / 5 (1) |
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Study suggests caution and further studies on drugs used to treat macular degeneration
Millions of people with "wet" macular degeneration are prescribed a class of medication known as anti-VEGF drugs. But now scientists at The Scripps Research Institute (TSRI) have found that a drastic reduction of VEGF activity ...
Cancer
Oct 25, 2012 |
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Timing is everything when it comes to weight loss, research shows
Joint research between the University of Michigan and the Argentina-based National Council of Science and Technology (CONICET) has shed light on one of the most frustrating mysteries of weight loss – why the weight inevitably ...
Overweight and Obesity
Oct 24, 2012 |
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Research findings breathe new life into lung disease
It turns out the muscle cells on the outside of blood vessels have been wrongly accused for instigating lung disease. New research shows that while these muscle cells are responsible for constricting or dilating the blood ...
Medical research
Oct 24, 2012 |
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