Journal of Clinical Investigation
Study suggests caution and further studies on drugs used to treat macular degeneration
Millions of people with "wet" macular degeneration are prescribed a class of medication known as anti-VEGF drugs. But now scientists at The Scripps Research Institute (TSRI) have found that a drastic reduction of VEGF activity ...
Cancer
Oct 25, 2012 |
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Timing is everything when it comes to weight loss, research shows
Joint research between the University of Michigan and the Argentina-based National Council of Science and Technology (CONICET) has shed light on one of the most frustrating mysteries of weight loss – why the weight inevitably ...
Overweight and Obesity
Oct 24, 2012 |
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Research findings breathe new life into lung disease
It turns out the muscle cells on the outside of blood vessels have been wrongly accused for instigating lung disease. New research shows that while these muscle cells are responsible for constricting or dilating the blood ...
Medical research
Oct 24, 2012 |
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Study identifies biological mechanism that plays key role in early-onset dementia
Using animal models, scientists at the Gladstone Institutes have discovered how a protein deficiency may be linked to frontotemporal dementia (FTD)—a form of early-onset dementia that is similar to Alzheimer's disease. ...
Neuroscience
Oct 08, 2012 |
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Endotrophin links obesity to breast cancer progression
Fat cells (adipocytes) surround breast tumors and contribute to tumor growth by expressing factors that aid oncogenesis. Col6 is a protein that is highly expressed in adipocytes and its expression is further increased in ...
Cancer
Oct 08, 2012 |
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Bitter taste receptors regulate the upper respiratory defense system, research shows
A new study from a team of researchers at the Perelman School of Medicine at the University of Pennsylvania, the Monell Chemical Senses Center, and the Philadelphia VA Medical Center, reveals that a person's ability to taste ...
Medical research
Oct 08, 2012 |
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Putting a 'HEX' on muscle regeneration
A complex genetic regulatory network mediates the regeneration of adult skeletal muscles. In this issue of the Journal of Clinical Investigation, researchers at the State University of New York Downstate Medical Center in Bro ...
Medical research
Oct 01, 2012 |
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NIH launches trial for rare degenerative muscle disease treatment
Researchers have launched a clinical trial to evaluate the drug candidate DEX-M74 as a treatment for a rare degenerative muscle disease, hereditary inclusion body myopathy (HIBM). National Institutes of Health scientists ...
Medical research
Sep 24, 2012 |
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Small proteins in the cornea protect against bacterial infection
When it comes to germ-busting power, the eyes have it, according to a discovery by University of California, Berkeley, researchers that could lead to new, inexpensive antimicrobial drugs.
Medical research
Sep 24, 2012 |
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Cystic fibrosis disrupts pancreas two ways in CF-related diabetes
A new University of Iowa study suggests there are two root causes of a type of diabetes associated with cystic fibrosis (CF). The findings, which already have sparked a clinical trial, may guide development ...
Diabetes
Sep 17, 2012 |
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Toxic protein build-up in blood shines light on Huntington's disease
A new light-based technique for measuring levels of the toxic protein that causes Huntington's disease (HD) has been used to demonstrate that the protein builds up gradually in blood cells. Published today ...
Neuroscience
Sep 17, 2012 |
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Mathematical model may lead to safer chemotherapy
Cancer chemotherapy can be a life-saver, but it is fraught with severe side effects, among them an increased risk of infection. Until now, the major criterion for assessing this risk has been the blood cell count: if the ...
Medical research
Sep 12, 2012 |
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Researchers identify possible new oncogene and future therapy target
A gene that may possibly belong to an entire new family of oncogenes has been linked by researchers with the U.S. Department of Energy (DOE)'s Lawrence Berkeley National Laboratory (Berkeley Lab) to the resistance ...
Cancer
Sep 11, 2012 |
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Metastatic 'switch' could lead to cancer therapies
(Medical Xpress)—What kills cancer patients often isn't the primary tumor; it's when the tumor metastasizes—or spreads the cancer to other areas of the body.
Cancer
Sep 11, 2012 |
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'Humanized' mice enable malaria research breakthrough
A novel human liver-chimeric mouse model developed at Oregon Health & Science University and Yecuris Corporation has made possible a research breakthrough at Seattle Biomedical Research Institute that will ...
Medical research
Sep 10, 2012 |
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