Journal of Clinical Investigation

Oncology & Cancer

Molecular mechanisms reveal how to make the most of methotrexate

St. Jude Children's Research Hospital scientists have identified factors that influence how children with acute lymphoblastic leukemia (ALL) respond to methotrexate. High-dose methotrexate is a part of modern curative therapy ...

Medical research

A potential agent for treating preeclampsia

Preeclampsia usually begins after the 20th week of pregnancy. The affected women suddenly develop high blood pressure, they excrete increased amounts of protein in their urine (called proteinuria)—a sign that the small ...

Medical research

Visceral fat delivers signal to the brain that hurts cognition

Excessive weight around our middle gives our brain's resident immune cells heavy exposure to a signal that turns them against us, setting in motion a crescendo of inflammation that damages cognition, scientists say.

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