Journal of Experimental Medicine

Oncology & Cancer

Exploring the biology of 'double positive' T cells

The molecular markers CD4 and CD8—defining helper T cells and killer T cells, respectively—were once considered mutually exclusive. But "double positive" CD4+-CD8+ T cells have lately been discovered in people in various ...

Immunology

Study identifies key player in T cell 'education'

Vanderbilt researchers have identified a protein that is key to the "education" of immature T cells in the thymus. The findings, reported in the Journal of Experimental Medicine, could inform therapeutic strategies for enhancing ...

Cardiology

Mechanism discovered that leads to ANCA-associated vasculitis

The immune system can become the enemy when mechanisms that are actually protective get out of control. In ANCA-associated vasculitis, excessive inflammatory reactions lead to pulmonary hemorrhages that can be fatal if left ...

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