Journal of General Physiology

Medical research

Tweaking energy consumption to combat muscle wasting and obesity

Using a new technique to evaluate working muscles in mice, researchers have uncovered physiological mechanisms that could lead to new strategies for combating metabolism-related disorders like muscle wasting and obesity. ...

Medical research

Controlling our circadian rhythms

Most people have experienced the effects of circadian-rhythm disruption, after traveling across time zones or adjusting to a new schedule. To have any hope of modulating our biological "clocks," to combat jet lag or cope ...

Medical research

Identifying a mystery channel crucial for hearing

Our ability to hear relies on hair cells, sensory receptors that mechanically amplify low-level sound that enters the inner ear through a transduction channel. Although the transduction channel was characterized more than ...

Cardiology

Understanding the role of IKACh in cardiac function

Researchers have uncovered a previously unknown role for the acetylcholine-activated inward-rectifying potassium current (IKACh) in cardiac pacemaker activity and heart rate regulation, according to a study in The Journal ...

Diseases, Conditions, Syndromes

How cholera-causing bacteria respond to pressure

Cholera remains common in non-industrialized parts of the world today. It persists in part because V. cholera, the bacteria that causes the disease, is able to survive in diverse environments ranging from the intestinal lumen, ...

Medical research

New methods to explore astrocyte effects on brain function

A study in The Journal of General Physiology presents new methods to evaluate how astrocytes contribute to brain function, paving the way for future exploration of these important brain cells at unprecedented levels of detail.

Diseases, Conditions, Syndromes

Researchers explore PKC role in lung disease

New research examines the role of PKC in airway smooth muscle contraction and raises the possibility that this enzyme could be a therapeutic target for treating asthma, COPD, and other lung diseases.

Medical research

Study offers new insights into the mechanics of muscle fatigue

A study in The Journal of General Physiology examines the consequences of muscle activity with surprising results, indicating that the extracellular accumulation of potassium that occurs in working muscles is considerably ...

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