Journal of the American Society of Nephrology

Diseases, Conditions, Syndromes

Talking receptors may affect relaxin at work

Fibrosis, the damaging build-up of hardened or scarred tissue in the body, is a hallmark of various diseases and can lead to the dysfunction and failure of organs such as the heart and kidney. Fibrosis-related diseases in ...

Medical research

Scientists reveal how a faulty gene leads to kidney disease

New insights into why a faulty gene involved in a devastating form of a kidney condition called nephrotic syndrome leads to disease in some patients have been identified in new Kidney Research UK-funded research led by the ...

Diseases, Conditions, Syndromes

New window on fibrosis

DDR1 is a receptor tyrosine kinase (RTK)—a cell surface receptor—that regulates multiple functions including the maintenance of the normal structure of tissues, but which also contributes to pathological conditions including ...

Diseases, Conditions, Syndromes

Sex differences in kidney injury

Evidence indicates men have higher incidence of chronic kidney disease and quicker renal decline than premenopausal women. However, sex differences in the expression and activation of the EGF receptor (EGFR), which mediates ...

Diseases, Conditions, Syndromes

Higher eGFR at dialysis initiation tied to lower survival in children

(HealthDay)—In children with end-stage renal disease (ESRD), a higher estimated glomerular filtration rate (eGFR) at dialysis initiation is associated with lower survival, particularly among children whose initial treatment ...

page 8 from 37