Molecular and Cellular Biology

Enzyme's alter ego helps activate the immune system

Already known to cut proteins, the enzyme SPPL3 turns out to have additional talents, according to a new study from Johns Hopkins. In its newly discovered role, SPPL3 works without cutting proteins to activate T cells, the ...

Dec 29, 2014
popularity 5 / 5 (10) | comments 1

Single enzyme is necessary for development of diabetes

An enzyme called 12-LO promotes the obesity-induced oxidative stress in the pancreatic cells that leads to pre-diabetes, and diabetes. 12-LO's enzymatic action is the last step in the production of certain small molecules ...

Aug 14, 2014
popularity 4.4 / 5 (5) | comments 0

Shape-shifting stops migrating cancer cells

Like a car with a front and back end, a steering mechanism and an engine to push it forward, cancer cells propel themselves through normal tissues and organs to spread cancer throughout the body. Researchers at Mayo Clinic ...

Dec 04, 2013
popularity 4.5 / 5 (2) | comments 0

New technique catalogs lymphoma-linked genetic variations

(Medical Xpress)—As anyone familiar with the X-Men knows, mutants can be either very good or very bad—or somewhere in between. The same appears true within cancer cells, which may harbor hundreds of mutations that set ...

Dec 27, 2012
popularity 5 / 5 (1) | comments 0

Hydrogen sulfide: The next anti-aging agent?

Hydrogen sulfide (H2S) may play a wide-ranging role in staving off aging, according to a paper published online ahead of print in the journal Molecular and Cellular Biology. In this review article, a team from China explor ...

Jan 29, 2013
popularity 5 / 5 (1) | comments 0