Molecular Cell

Oncology & Cancer

New drug targets for BRCA-driven cancer uncovered

BRCA1 and BRCA2 ("BReast CAncer genes") are critical tumor suppressor genes—women carrying a mutation in one of these genes have up to an 80 percent risk of developing breast cancer and a 50 percent risk of developing ovarian ...

Genetics

Unraveling a genetic network linked to autism

Donnelly Centre researchers have uncovered a genetic network linked to autism. The findings, described in the journal Molecular Cell, will facilitate developing new therapies for this common neurological disorder.

Medical research

Study opens new therapeutic avenue for mitochondria malfunction

A surprising offender has been emerging to drive the progression of Parkinson's, Alzheimer's, Huntington's and other neurodegenerative diseases: calcium. Calcium controls the production of fuel in mitochondria, the cell's ...

Medical research

'Cellular memory' of DNA damage in oocyte quality control

Females are born with a finite number of eggs that are steadily depleted throughout their lifetime. This reserve of eggs is selected from a much larger pool of millions of precursor cells, or oocytes, that form during fetal ...

Immunology

How our immune system detects broken DNA

Our immune system is working every day to protect us from bacteria, viruses, and parasites, but it can also detect when our own cells are damaged.

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