Smoking can double risk of colorectal polyps

February 1, 2008

Smokers have a two-fold increased risk of developing colorectal polyps, the suspected underlying cause of most colorectal cancers (CRC), according to a study published in Gastroenterology, the official journal of the American Gastroenterological Association (AGA) Institute.

The results from this meta-analysis showed pooled risk estimates of 2.14 for current versus never smokers, 1.82 for ever versus never smokers and 1.47 for former versus never smokers. Ever smokers had a 13 percent increasing risk of polyps for every additional 10 pack-years smoked in comparison to never smokers. For example, an individual who smoked one pack of cigarettes per day for 50 years or two packs a day for 25 years had almost twice the probability for developing colorectal polyps compared to an individual who never smoked.

The results of this meta-analysis suggest that approximately 20 percent to 25 percent of colorectal polyps may be attributed to smoking. Risk was significantly greater for high-risk polyps, indicating that smoking may be important for the transformation of polyps into cancer. The study findings are potentially important for determining the age of onset of colorectal cancer screening.

“While the harmful health effects of tobacco smoking are well known, smoking has not been considered so far in the stratification of patients for CRC screening. Our findings could support lowering the recommended age for smokers to receive colorectal cancer screening,” said Albert B. Lowenfels, MD, senior author of the study, from New York Medical College, Valhalla, New York.

At present, evidence of a role for tobacco smoking on the development of CRC is still controversial. One explanation could be that CRC develops much later in life than polyps; the long latency period makes it difficult to establish a firm link between smoking and CRC.

The study was performed at the Division of Epidemiology and Biostatistics, European Institute of Oncology, Milan, Italy where the lead author, Edoardo Botteri, performed the analysis based on the combined evidence from 42 independent observational studies.

Source: American Gastroenterological Association

Explore further: Improving participation in cancer screening should be a priority

Related Stories

Dose-response pattern for smoking, colorectal neoplasm

October 30, 2015

(HealthDay)—Colorectal neoplasm (CRN) is associated with smoking in a dose-response manner, but not with alcohol intake, according to a study published online Oct. 19 in the Journal of Gastroenterology and Hepatology.

Lighting up can bring you down in colorectal surgery

September 24, 2013

Infection, pneumonia, blood clots and kidney failure are all possible complications after any major surgery. A new study shows that smoking boosts the risk of such complications following some of the most common colorectal ...

Cigarette smoking's impact lingers after quitting

October 31, 2011

Cigarette smoking appears to impair pancreatic duct cell function--even for those who quit--putting all smokers at risk of compromised digestive function regardless of age, gender and alcohol intake, according to the results ...

Recommended for you

Want to exercise more? Get yourself some competition

October 27, 2016

Imagine you're a CEO trying to get your employees to exercise. Most health incentive programs have an array of tools—pamphlets, websites, pedometers, coaching, team activities, step challenges, money—but what actually ...


Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.