Red wine ingredient wards off effects of age on heart, bones, eyes and muscle

July 3, 2008

Large doses of a red wine ingredient can ward off many of the vagaries of aging in mice who begin taking it at midlife, according to a new report published online on July 3rd in Cell Metabolism, a Cell Press publication. Those health improvements of the chemical known as resveratrol—including cardiovascular benefits, greater motor coordination, reduced cataracts and better bone density—come without necessarily extending the animals' lifespan.

Sinclair and de Cabo's team further show evidence that resveratrol mimics the beneficial effects of eating fewer calories. In mice, they found that resveratrol induces gene activity patterns in multiple tissues that parallel those induced by dietary restriction and every-other-day feeding.

" From a health point of view, the quality of life of these mice at the end of their days is much better," said Rafael de Cabo of the National Institute on Aging. It suggests that resveratrol may "extend productive independent life, rather than just extending life span."

" I was most surprised by how broad the effects were in the mice," added David Sinclair of Harvard Medical School. "Usually, you focus on slowing down or ameliorating one disease at a time. In this case, resveratrol influences a whole series of seemingly unrelated diseases associated with aging." Sinclair said he expects some of the effect seen in the mice would have even greater impact if they hold in humans. That's because, unlike people, mice usually don't die as a result of heart disease, or suffer from weakening bones.

Earlier studies showed that reducing calorie intake by 30%󈞞%, or eating a nutritious diet every other day, can delay the onset of age-related diseases, improve stress resistance, and decelerate functional decline, the researchers said. Although dietary restriction has beneficial effects in humans, such a diet is unlikely to be widely adopted and would pose a significant risk to the frail, critically ill, or the elderly.

Therefore, the researchers are on a quest for "dietary restriction mimetic" compounds that provide some of the benefits without cutting calories. One contender has been compounds like resversatrol that activate SIRT1, a protein linked to long life in many species, from yeast to mammals.

Resveratrol produced changes in the gene expression profiles of key metabolic tissues, including liver and muscle, that closely resemble those induced by dietary restriction, they report. Overall, the animals' health improved under all dietary conditions, as reflected by a reduction of osteoporosis, cataracts, vascular dysfunction, and declines in motor coordination. However, the mice lived longer only when they were fed a high-calorie diet, consistent with earlier reports.

" In conclusion, long-term resveratrol treatment of mice can mimic transcriptional changes induced by dietary restriction and allow them to live healthier, more vigorous lives," they wrote. "In addition to improving insulin sensitivity and increasing survival in [high-calorie fed] mice, we show that resveratrol improves cardiovascular function, bone density, and motor coordination, and delays cataracts, even in nonobese rodents. Together, these findings confirm the feasibility of finding an orally available dietary restriction mimetic."

Resveratrol treatment is already being tested in clinical trials for type II diabetes, the researchers noted, and more potent molecules with effects similar to resveratrol are also under development.

Source: Cell Press

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not rated yet Jul 07, 2008
My story starts in early November 2005. During an abdominal echographic exam aiming to determine the health status of the liver, a kidney cancer was detected. Then a multitude of tests like CT scan, PET scan, Scintiscan, electrocardiograms were conducted. The verdict was a kidney cancer with metastases in the lungs. The prognostic was of 2 years at the most. And that was without taking my heart condition into account! I had an infarcts in June 2003 plus the aortic valve which is impaired.

Finally in March 2006 the right kidney is removed. Then in July 2006 I undergo thoracic surgery to removed the biggest metastases. I'm left with a "multitude of small nodules", these are the words used in the radiology report. In September 2006 I begin a chemotherapy. The new drug taken orally brigs a lost of hair, skin rashes, diarrhea and hypertension. By June 2007 I must be hospitalized and a Stent is place in the right coronary artery. In July I receive a new drug. I must thank the drug manufacturer who covered the $800/month that my insurance did not covered. The secondary effects are less severe than the previous drug but my heart is seriously affected. By November 2007 I can't climb more than 5 steps without having to vaporize nitro under the thong. At this point I believe that my 2 years are up and it's time to say "au revoir" . On December 27 2007 I'm hospitalized with cardiac deficiency, pulmonary edema, edema of the extremities, epistaxis (nose bleed) and anemia. This time I truly believe that my number is up.

Back in November, I read a book written by a fiend and former colleague, Dr. Richard Béliveau. The tittle in French is: Les aliments contre le cancer.(Food Against Cancer). With the inconveniences of winter storm plus the Holiday season I received my first shipment of resveratrol (Transmax) by the end of December. I immediately started taking 500 mg 4 times a day but kept on taking the prescribed drug. Further more, I also take 10 ml of a mixture composed of curcuma, crushed black pepper and linseed oil.

Within 3 weeks a miracle took place. Is it the prayers (I'm a scientist but also a believer), the Transmax, the curcuma or the prescribed drug? I will never know for sure but You will not catch me without Transmax. In March I participated in a badminton tournament, in April I led a dog slay. I have activities that were left aside for more than 2 years. My girl friend (11 years younger than I) will not allow me to go without Transmax. She is also taking Transmax because she wants to look as young as I (67 y.o).

The most important news came on April 29, 2008. The scan taken on April first 2008 shows that there are only 2 nodules remaining. They are described as follow:1- small non specific micro-nodule of 3 millimeters; 2- small thickening of 1.3 X 0.4 mm on the bottom left.

I pray for all of you afflicted by disease. Heaven helps those that help themselves.

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