JAX publishes online tool for exploring autoimmune disease gene networks

October 29, 2009
The gene networks illustrated in "Pathways to Discovery: Autoimmune Diseases" promise to facilitate the discovery of targeted therapies for many autoimmune diseases. Credit: The Jackson Laboratory

Currently, 5-8% of the U.S. population is afflicted with an autoimmune disease. Many of these are chronic and require life-long care. Moreover, different autoimmune diseases aggregate within a single family, suggesting they are caused by disruptions in common biological pathways.

To help researchers investigate these common pathways, The Jackson Laboratory has published "Pathways to Discovery: Autoimmune Diseases" (www.jax.org/jaxmice/pathways/autoimmune), a unique, interactive, and publicly accessible online resource that illustrates the genetic networks involved in five common autoimmune diseases: , rheumatoid arthritis, asthma, multiple sclerosis, and .

The backbone of the new tool is five "spider-web" diagrams that depict the gene/proteins involved in two or more of the five diseases. The symbols in the diagrams represent cytokines, transmembrane receptors, enzymes, nuclear receptors, and transcriptional regulators. The resource also provides gene- and disease-specific references, links to JAX® Mice strains (including inducible mouse models) that can be used to research the five diseases, and descriptions of JAX® In Vivo Services for compound efficacy testing.

"Pathways to Discovery: " promises to accelerate the discovery of autoimmune disease mechanisms and therapeutic interventions for both new and existing targets.

Source: Jackson Laboratory

Related Stories

Recommended for you

Natural compound reduces signs of aging in healthy mice

October 27, 2016

Much of human health hinges on how well the body manufactures and uses energy. For reasons that remain unclear, cells' ability to produce energy declines with age, prompting scientists to suspect that the steady loss of efficiency ...

A metabolic switch to turn off obesity

October 27, 2016

You've tried all the diets. No matter: you've still regained the weight you lost, even though you ate well and you exercised regularly! This may be due to a particular enzyme in the brain: the alpha/beta hydrolase domain-6 ...

Scientists develop 'world-first' 3-D mammary gland model

October 27, 2016

A team of researchers from Cardiff University and Monash Biomedicine Discovery Institute has succeeded in creating a three-dimensional mammary gland model that will pave the way for a better understanding of the mechanisms ...


Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.