Patients with Irritable Bowel Syndrome not more likely to develop polyps, colon cancer

March 9, 2010

Patients with irritable bowel syndrome are at no greater risk of having polyps, colon cancer or inflammatory bowel diseases than healthy people undergoing colonoscopies, according to new research published in the American Journal of Gastroenterology.

"Patients and doctors get nervous about the symptoms of (IBS)," says William D. Chey, M.D., professor of Internal Medicine at the University of Michigan Medical School. "They think the symptoms represent something more sinister."

"This study should reassure doctors and patients that typical IBS symptoms are not indicators of a more serious disease," he adds.

Chey was the lead author on the study, the largest prospective evaluation of the results of colonoscopies in patients with irritable bowel syndrome.

IBS symptoms include recurrent episodes of abdominal pain or cramping in connection with altered bowel habits. The condition affects 10 to 20 percent of the U.S. population and is more common among women than men. Many of those afflicted never seek treatment.

IBS patients often undergo colonoscopies because physicians are particularly concerned about missing colorectal cancer or inflammatory bowel diseases like or Crohn's disease, Chey says. Roughly a quarter of all colonoscopies performed in the U.S. are for IBS-related symptoms.

This research shows that it is unnecessary to order colonoscopies for IBS patients, unless they show other alarming symptoms like unexplained weight loss or anemia, bleeding from the GI tract, or have a family history of , or celiac disease, says Chey, who also is director of U-M's Gastrointestinal Physiology Laboratory and the Michigan Bowel Control Program.

"Lay people and doctors overuse colonoscopies, which are very expensive procedures, in patients with typical IBS symptoms and no alarm features. Of course, patients over the age of 50 years or who have alarm features should undergo colonoscopy to screen for polyps and ." Chey says.

Chey's research also showed that a small percentage of IBS patients older than 35 (2.5%) had an unusual disease called microscopic colitis. Microscopic colitis can masquerade as IBS in patients with diarrhea and is important to diagnose because it is treated differently than IBS, he says.

More information: More information about colorectal cancer can be found at

Related Stories

Recommended for you

Zika virus infection alters human and viral RNA

October 20, 2016

Researchers at University of California San Diego School of Medicine have discovered that Zika virus infection leads to modifications of both viral and human genetic material. These modifications—chemical tags known as ...

Food-poisoning bacteria may be behind Crohn's disease

October 19, 2016

People who retain a particular bacterium in their gut after a bout of food poisoning may be at an increased risk of developing Crohn's disease later in life, according to a new study led by researchers at McMaster University.


Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.