Noninvasively seeing a clear picture of immune cell function in vivo

Immune cell function in an individual can be monitored noninvasively in the clinic using a technique known as a PET scan.

A team of researchers, led by Owen Witte, at the University of California, Los Angeles, has now determined that in two different PET probes used in the clinic to monitor immune cell function detect distinct immune cell populations. These data have implications for the interpretation of clinical PET scans performed with these two probes and suggest these probes could be used in the clinic to monitor the effects of drugs designed to target specific immune cell populations.

Immune cells use more glucose as their energy source when active. There are specific PET probes that can be used to detect this switch to increased glucose utilization. In this study, the researchers found that in mice with a retrovirus-induced sarcoma (a form of cancer that arises from connective tissue cells such as bone, , and ) two PET probes that detect increased glucose utilization (FDG and FAC) accumulated in different immune cell populations.

Specifically, FDG accumulated mainly in innate , while FAC accumulated predominantly in active CD8+ T cells. These data suggest that PET could be used more widely than it is currently to noninvasively evaluate the effectiveness of numerous immune modulating therapies.

More information: View this article at: www.jci.org/articles/view/4125 … d8b807a4c80caaba59dd

Provided by Journal of Clinical Investigation
Citation: Noninvasively seeing a clear picture of immune cell function in vivo (2010, May 17) retrieved 29 March 2024 from https://medicalxpress.com/news/2010-05-noninvasively-picture-immune-cell-function.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.

Explore further

Researchers develop new PET scanning probe that will allowing monitoring of the immune system

 shares

Feedback to editors