Thuricin CD tested as specific antibiotic for Clostridium difficile

May 3, 2010

A University of Alberta researcher is part of an international team that has discovered a naturally occurring micro-organism that directly targets a bacteria that causes a sometimes deadly intestinal disease in young children and the elderly.

John Vederas, a U of A chemistry researcher working with colleagues in Ireland, found that a strain of the common soil bacteria, Bacillus thuringiensis, produces thuricin CD, a 1:1 mixture of two compounds () that kills the potentially deadly bacteria, Clostridium difficile. But unlike other antibacterial agents, thuricin CD does no harm to other bacteria in the human gut, which are necessary for a balanced state of health.

Clostridium difficile causes abdominal pain and diarrhea that can require hospitalization. Outbreaks of the disease can be deadly in long-term care facilities. Provincial health officials in Quebec listed a Clostridium difficile outbreak as the direct cause of death for more than 1,000 people between 2003 and 2004.

When a is treated with a broad spectrum antibiotic, it clears all the from the gut and Clostridium difficile can take quickly take hold.

Thuricin CD has shown promising results as a specific for Clostridium difficile in vitro and is now being tested in animals.

More information: Vederas is co author of a paper on thuricin CD published this month in Proceedings of the National Academy of Sciences USA.

Related Stories

Recommended for you

TET proteins drive early neurogenesis

December 7, 2016

The fate of stem cells is determined by series of choices that sequentially narrow their available options until stem cells' offspring have found their station and purpose in the body. Their decisions are guided in part by ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.