New hope for hard-to-treat heart patients with balloon angioplasty

November 4, 2010

In some heart patients, coronary arteries become so clogged that they are difficult or impossible to reopen with conventional balloon angioplasties.

Dr. John Lopez of Loyola University Health System is using a new angioplasty technique to reopen these tough by going through the "back door."

The technique, called retrograde recanalization, was developed in Japan and is beginning to catch on in centers with advanced expertise in . It is a complex procedure that requires new catheters and tools that can pass through less than 1 millimeter wide.

Lopez recently used the technique on Heliodoro Galvan, 55, of Oak Forest, Ill. Before the procedure, Galvan's right was completely blocked, causing fatigue and difficulty breathing.

In a conventional angioplasty, an interventional cardiologist inserts a catheter through an artery in the groin and guides it to the front end of the blockage. The catheter is passed through the blockage and a balloon on the tip of the catheter is inflated to open the artery. The cardiologist typically deploys a stent, or a wire mesh tube, to keep the artery open.

But in Galvan's case, the front of the blockage was clogged with bone-hard deposits. So Lopez took a different route. He approached the blockage from the back end, which was softer and easier to break through with a .

To reach this back end, Lopez took an alternative route that passed through narrow "collateral" arteries that are 0.5 millimeter to 1 millimeter wide. (These collateral arteries sprouted up after the right coronary artery closed up.)

Before undergoing the procedure, Galvan experienced unusual fatigue. He nearly fainted a few times at his physically demanding job. Spending a day with his grandchildren left him exhausted. And he couldn't run more than half the length of a football field without becoming winded.

Galvan underwent the procedure Aug. 24 and went home the next day. Today, he has much more energy and can run easily for 5 or 10 minutes without stopping. He walks and jogs three or four miles every other day. He also has improved his diet and lost about 20 pounds.

"I feel a lot better," he said. "Finally, I can go for a run."

Lopez is director of interventional cardiology research and a professor in the cardiology division of the Department of Medicine of Loyola University Chicago Stritch School of Medicine.

Related Stories

Recommended for you

Natural compound reduces signs of aging in healthy mice

October 27, 2016

Much of human health hinges on how well the body manufactures and uses energy. For reasons that remain unclear, cells' ability to produce energy declines with age, prompting scientists to suspect that the steady loss of efficiency ...

A metabolic switch to turn off obesity

October 27, 2016

You've tried all the diets. No matter: you've still regained the weight you lost, even though you ate well and you exercised regularly! This may be due to a particular enzyme in the brain: the alpha/beta hydrolase domain-6 ...

Mitochondria control stem cell fate

October 27, 2016

What happens in intestinal epithelial cells during a chronic illness? Basic research conducted at the Chair of Nutrition and Immunology at the Technical University of Munich (TUM) addressed this question by generating a new ...

Scientists develop 'world-first' 3-D mammary gland model

October 27, 2016

A team of researchers from Cardiff University and Monash Biomedicine Discovery Institute has succeeded in creating a three-dimensional mammary gland model that will pave the way for a better understanding of the mechanisms ...


Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.